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    Determination of Optimum Design Parameters for Gyroid Scaffolds to Mimic a Real Bone-Like Condition In Vitro: A Fluid Structure Interaction Study

    Source: Journal of Engineering and Science in Medical Diagnostics and Therapy:;2023:;volume( 006 ):;issue: 003::page 30909-1
    Author:
    Gupta, Abhisek
    ,
    Rana, Masud
    ,
    Mondal, Nitesh
    DOI: 10.1115/1.4062614
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: A suitable scaffold architecture is always desirable to get a biomimetic scaffold for bone tissue engineering. In this regard, a fluid structure interaction analysis was carried out on different Micro-CTs (μCTs) and gyroids to observe the in vitro mechanical responses due to fluid flow. Computational fluid dynamics method was used to evaluate the permeability and wall shear stress (WSS), followed by a finite element method to obtain the mechanical stress within scaffolds. Different types of gyroids were designed based on the number of unit cells and porosity, where porosity of gyroids was kept same as μCTs. The main objective of the study is to examine the variations of permeability, WSS and mechanical stress with respect to the number of unit cells and porosity for different gyroids and μCTs. Mechanical responses were also compared between gyroids and μCTs. The results of this study highlighted that permeability and WSS of μCTs came close to the gyroids with eight unit cells but had significant differences in mechanical stress. The permeability of gyroids increased with the increase of porosity but decreased with the increase in number of unit cells. The opposite trend was shown in case of WSS within gyroids. This study will guide us in predicting an ideal scaffold for trabecular bone replacement.
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      Determination of Optimum Design Parameters for Gyroid Scaffolds to Mimic a Real Bone-Like Condition In Vitro: A Fluid Structure Interaction Study

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    http://yetl.yabesh.ir/yetl1/handle/yetl/4294610
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    contributor authorGupta, Abhisek
    contributor authorRana, Masud
    contributor authorMondal, Nitesh
    date accessioned2023-11-29T19:08:43Z
    date available2023-11-29T19:08:43Z
    date copyright6/7/2023 12:00:00 AM
    date issued6/7/2023 12:00:00 AM
    date issued2023-06-07
    identifier issn2572-7958
    identifier otherjesmdt_006_03_030909.pdf
    identifier urihttp://yetl.yabesh.ir/yetl1/handle/yetl/4294610
    description abstractA suitable scaffold architecture is always desirable to get a biomimetic scaffold for bone tissue engineering. In this regard, a fluid structure interaction analysis was carried out on different Micro-CTs (μCTs) and gyroids to observe the in vitro mechanical responses due to fluid flow. Computational fluid dynamics method was used to evaluate the permeability and wall shear stress (WSS), followed by a finite element method to obtain the mechanical stress within scaffolds. Different types of gyroids were designed based on the number of unit cells and porosity, where porosity of gyroids was kept same as μCTs. The main objective of the study is to examine the variations of permeability, WSS and mechanical stress with respect to the number of unit cells and porosity for different gyroids and μCTs. Mechanical responses were also compared between gyroids and μCTs. The results of this study highlighted that permeability and WSS of μCTs came close to the gyroids with eight unit cells but had significant differences in mechanical stress. The permeability of gyroids increased with the increase of porosity but decreased with the increase in number of unit cells. The opposite trend was shown in case of WSS within gyroids. This study will guide us in predicting an ideal scaffold for trabecular bone replacement.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleDetermination of Optimum Design Parameters for Gyroid Scaffolds to Mimic a Real Bone-Like Condition In Vitro: A Fluid Structure Interaction Study
    typeJournal Paper
    journal volume6
    journal issue3
    journal titleJournal of Engineering and Science in Medical Diagnostics and Therapy
    identifier doi10.1115/1.4062614
    journal fristpage30909-1
    journal lastpage30909-7
    page7
    treeJournal of Engineering and Science in Medical Diagnostics and Therapy:;2023:;volume( 006 ):;issue: 003
    contenttypeFulltext
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