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    A Study on Mechanical Damage of Tumor Microvasculature Induced by Alternate Cooling and Heating

    Source: Journal of Thermal Science and Engineering Applications:;2009:;volume( 001 ):;issue: 003::page 31002
    Author:
    Yuanyuan Shen
    ,
    Lisa X. Xu
    ,
    Aili Zhang
    DOI: 10.1115/1.4000582
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Tumor microvascular damage caused by the alternate cooling and heating treatment was found much more severe than that of cooling or heating alone from our previous experimental studies. The induced stresses on the vessel wall are expected to play an important role in vascular damage. Both thermal and mechanical stresses are involved due to the rapid changes in temperature and blood reperfusion during the treatment. To investigate the stress effect, theoretical modeling and numerical simulations have been performed in the present study. Thermal stresses on the tumor microvessel wall during the freezing process are analyzed using the elastic models through the coupled field method. To simulate mechanical stresses induced by blood reperfusion, the fluid and structural mechanics are coupled on the interface between the blood flow domain and the vessel wall. Numerical results show that the thermal stress on the vessel wall is negative in the tumor center, indicating the compression effect during the freezing process. The magnitude of the radial stress reaches 2.5×107 dyn/cm2. During the postheating process, the nonuniform stress distribution exists in the tortuous periphery vessel wall owing to the irregular structures, and higher stresses normally appear at the vessel bifurcations. Synergy of the thermal and mechanical stresses on the vessel wall play critical roles in damaging of the heterogeneous tumor vasculature during the alternate cooling and heating treatment. Results obtained in the present study are expected to help better understand the vascular injury process, and to develop a more effective thermal treatment protocol for tumor therapy.
    keyword(s): Temperature , Freezing , Stress , Thermal stresses , Blood , Heating and cooling , Tumors , Vessels , Heating , Blood flow , Biological tissues AND Cooling ,
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      A Study on Mechanical Damage of Tumor Microvasculature Induced by Alternate Cooling and Heating

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    http://yetl.yabesh.ir/yetl1/handle/yetl/141980
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    • Journal of Thermal Science and Engineering Applications

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    contributor authorYuanyuan Shen
    contributor authorLisa X. Xu
    contributor authorAili Zhang
    date accessioned2017-05-09T00:35:26Z
    date available2017-05-09T00:35:26Z
    date copyrightSeptember, 2009
    date issued2009
    identifier issn1948-5085
    identifier otherJTSEBV-28807#031002_1.pdf
    identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/141980
    description abstractTumor microvascular damage caused by the alternate cooling and heating treatment was found much more severe than that of cooling or heating alone from our previous experimental studies. The induced stresses on the vessel wall are expected to play an important role in vascular damage. Both thermal and mechanical stresses are involved due to the rapid changes in temperature and blood reperfusion during the treatment. To investigate the stress effect, theoretical modeling and numerical simulations have been performed in the present study. Thermal stresses on the tumor microvessel wall during the freezing process are analyzed using the elastic models through the coupled field method. To simulate mechanical stresses induced by blood reperfusion, the fluid and structural mechanics are coupled on the interface between the blood flow domain and the vessel wall. Numerical results show that the thermal stress on the vessel wall is negative in the tumor center, indicating the compression effect during the freezing process. The magnitude of the radial stress reaches 2.5×107 dyn/cm2. During the postheating process, the nonuniform stress distribution exists in the tortuous periphery vessel wall owing to the irregular structures, and higher stresses normally appear at the vessel bifurcations. Synergy of the thermal and mechanical stresses on the vessel wall play critical roles in damaging of the heterogeneous tumor vasculature during the alternate cooling and heating treatment. Results obtained in the present study are expected to help better understand the vascular injury process, and to develop a more effective thermal treatment protocol for tumor therapy.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleA Study on Mechanical Damage of Tumor Microvasculature Induced by Alternate Cooling and Heating
    typeJournal Paper
    journal volume1
    journal issue3
    journal titleJournal of Thermal Science and Engineering Applications
    identifier doi10.1115/1.4000582
    journal fristpage31002
    identifier eissn1948-5093
    keywordsTemperature
    keywordsFreezing
    keywordsStress
    keywordsThermal stresses
    keywordsBlood
    keywordsHeating and cooling
    keywordsTumors
    keywordsVessels
    keywordsHeating
    keywordsBlood flow
    keywordsBiological tissues AND Cooling
    treeJournal of Thermal Science and Engineering Applications:;2009:;volume( 001 ):;issue: 003
    contenttypeFulltext
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