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    Laminar Airflow and Nanoparticle or Vapor Deposition in a Human Nasal Cavity Model

    Source: Journal of Biomechanical Engineering:;2006:;volume( 128 ):;issue: 005::page 697
    Author:
    H. Shi
    ,
    C. Kleinstreuer
    ,
    Z. Zhang
    DOI: 10.1115/1.2244574
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: The transport and deposition of nanoparticles, i.e., dp=1–2nm, or equivalent vapors, in the human nasal cavities is of interest to engineers, scientists, air-pollution regulators, and healthcare officials alike. Tiny ultrafine particles, i.e., dp≤5nm, are of special interest because they are most rapidly absorbed and hence have an elevated toxic or therapeutic impact when compared to larger particles. Assuming transient laminar 3-D incompressible flow in a representative human nasal cavity, the cyclic airflow pattern as well as local and overall nanoparticle depositions were computationally simulated and analyzed. The focus was on transient effects during inhalation/exhalation as compared to the steady-state assumption typically invoked. Then, an equation for a matching steady-state inhalation flow rate was developed that generates the same deposition results as cyclic inhalation. Of special interest is the olfactory region where the narrow channel surfaces receive only about one-half of a percent of the inhaled nanoparticles because the airflow bypasses these recesses located in the superior-most portions in the geometrically complex nasal cavities.
    keyword(s): Flow (Dynamics) , Particulate matter , Air flow , Nanoparticles , Cavities , Equations AND Steady state ,
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      Laminar Airflow and Nanoparticle or Vapor Deposition in a Human Nasal Cavity Model

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    contributor authorH. Shi
    contributor authorC. Kleinstreuer
    contributor authorZ. Zhang
    date accessioned2017-05-09T00:18:51Z
    date available2017-05-09T00:18:51Z
    date copyrightOctober, 2006
    date issued2006
    identifier issn0148-0731
    identifier otherJBENDY-26616#697_1.pdf
    identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/133157
    description abstractThe transport and deposition of nanoparticles, i.e., dp=1–2nm, or equivalent vapors, in the human nasal cavities is of interest to engineers, scientists, air-pollution regulators, and healthcare officials alike. Tiny ultrafine particles, i.e., dp≤5nm, are of special interest because they are most rapidly absorbed and hence have an elevated toxic or therapeutic impact when compared to larger particles. Assuming transient laminar 3-D incompressible flow in a representative human nasal cavity, the cyclic airflow pattern as well as local and overall nanoparticle depositions were computationally simulated and analyzed. The focus was on transient effects during inhalation/exhalation as compared to the steady-state assumption typically invoked. Then, an equation for a matching steady-state inhalation flow rate was developed that generates the same deposition results as cyclic inhalation. Of special interest is the olfactory region where the narrow channel surfaces receive only about one-half of a percent of the inhaled nanoparticles because the airflow bypasses these recesses located in the superior-most portions in the geometrically complex nasal cavities.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleLaminar Airflow and Nanoparticle or Vapor Deposition in a Human Nasal Cavity Model
    typeJournal Paper
    journal volume128
    journal issue5
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.2244574
    journal fristpage697
    journal lastpage706
    identifier eissn1528-8951
    keywordsFlow (Dynamics)
    keywordsParticulate matter
    keywordsAir flow
    keywordsNanoparticles
    keywordsCavities
    keywordsEquations AND Steady state
    treeJournal of Biomechanical Engineering:;2006:;volume( 128 ):;issue: 005
    contenttypeFulltext
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