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contributor authorH. Shi
contributor authorC. Kleinstreuer
contributor authorZ. Zhang
date accessioned2017-05-09T00:18:51Z
date available2017-05-09T00:18:51Z
date copyrightOctober, 2006
date issued2006
identifier issn0148-0731
identifier otherJBENDY-26616#697_1.pdf
identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/133157
description abstractThe transport and deposition of nanoparticles, i.e., dp=1–2nm, or equivalent vapors, in the human nasal cavities is of interest to engineers, scientists, air-pollution regulators, and healthcare officials alike. Tiny ultrafine particles, i.e., dp≤5nm, are of special interest because they are most rapidly absorbed and hence have an elevated toxic or therapeutic impact when compared to larger particles. Assuming transient laminar 3-D incompressible flow in a representative human nasal cavity, the cyclic airflow pattern as well as local and overall nanoparticle depositions were computationally simulated and analyzed. The focus was on transient effects during inhalation/exhalation as compared to the steady-state assumption typically invoked. Then, an equation for a matching steady-state inhalation flow rate was developed that generates the same deposition results as cyclic inhalation. Of special interest is the olfactory region where the narrow channel surfaces receive only about one-half of a percent of the inhaled nanoparticles because the airflow bypasses these recesses located in the superior-most portions in the geometrically complex nasal cavities.
publisherThe American Society of Mechanical Engineers (ASME)
titleLaminar Airflow and Nanoparticle or Vapor Deposition in a Human Nasal Cavity Model
typeJournal Paper
journal volume128
journal issue5
journal titleJournal of Biomechanical Engineering
identifier doi10.1115/1.2244574
journal fristpage697
journal lastpage706
identifier eissn1528-8951
keywordsFlow (Dynamics)
keywordsParticulate matter
keywordsAir flow
keywordsNanoparticles
keywordsCavities
keywordsEquations AND Steady state
treeJournal of Biomechanical Engineering:;2006:;volume( 128 ):;issue: 005
contenttypeFulltext


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