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    Nanostructure, Effective Properties, and Deformation Pattern of the Cochlear Outer Hair Cell Cytoskeleton

    Source: Journal of Biomechanical Engineering:;2002:;volume( 124 ):;issue: 002::page 180
    Author:
    Alexander A. Spector
    ,
    Panos G. Charalambides
    ,
    Aleksander S. Popel
    ,
    Mohammed Ameen
    DOI: 10.1115/1.1448521
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: We consider the mechanical properties of the outer hair cell cytoskeleton. The cytoskeleton is represented as a set of microdomains of different sizes and orientations composed of actin filaments and spectrin crosslinks. An intermediate material between domains is also introduced. The domain characteristics are randomly generated and the histograms of the cytoskeleton stiffness moduli are obtained. We solve an inverse problem and estimate the stiffness of the crosslink and connective molecule in the intermediate material. We discovered a pattern of highly inhomogeneous deformation of the cytoskeleton where the circumferential strain is primarily determined by the deformation of the intermediate material.
    keyword(s): Deformation , Stiffness , Membranes , Shear (Mechanics) , Stress AND Anisotropy ,
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      Nanostructure, Effective Properties, and Deformation Pattern of the Cochlear Outer Hair Cell Cytoskeleton

    URI
    http://yetl.yabesh.ir/yetl1/handle/yetl/126404
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    • Journal of Biomechanical Engineering

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    contributor authorAlexander A. Spector
    contributor authorPanos G. Charalambides
    contributor authorAleksander S. Popel
    contributor authorMohammed Ameen
    date accessioned2017-05-09T00:06:52Z
    date available2017-05-09T00:06:52Z
    date copyrightApril, 2002
    date issued2002
    identifier issn0148-0731
    identifier otherJBENDY-26237#180_1.pdf
    identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/126404
    description abstractWe consider the mechanical properties of the outer hair cell cytoskeleton. The cytoskeleton is represented as a set of microdomains of different sizes and orientations composed of actin filaments and spectrin crosslinks. An intermediate material between domains is also introduced. The domain characteristics are randomly generated and the histograms of the cytoskeleton stiffness moduli are obtained. We solve an inverse problem and estimate the stiffness of the crosslink and connective molecule in the intermediate material. We discovered a pattern of highly inhomogeneous deformation of the cytoskeleton where the circumferential strain is primarily determined by the deformation of the intermediate material.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleNanostructure, Effective Properties, and Deformation Pattern of the Cochlear Outer Hair Cell Cytoskeleton
    typeJournal Paper
    journal volume124
    journal issue2
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.1448521
    journal fristpage180
    journal lastpage187
    identifier eissn1528-8951
    keywordsDeformation
    keywordsStiffness
    keywordsMembranes
    keywordsShear (Mechanics)
    keywordsStress AND Anisotropy
    treeJournal of Biomechanical Engineering:;2002:;volume( 124 ):;issue: 002
    contenttypeFulltext
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    DSpace software copyright © 2002-2015  DuraSpace
    نرم افزار کتابخانه دیجیتال "دی اسپیس" فارسی شده توسط یابش برای کتابخانه های ایرانی | تماس با یابش
    yabeshDSpacePersian