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contributor authorStrasser, Wayne
date accessioned2025-04-21T10:35:31Z
date available2025-04-21T10:35:31Z
date copyright10/11/2024 12:00:00 AM
date issued2024
identifier issn0148-0731
identifier otherbio_146_12_121011.pdf
identifier urihttp://yetl.yabesh.ir/yetl1/handle/yetl/4306507
description abstractAlzheimer's disease is a progressive degenerative condition that has various levels of effect on one's memory. It is thought to be caused by a buildup of protein in small fluid-filled spaces in the brain called perivascular spaces (PVS). The PVS often takes on the form of an annular region around arteries and is used as a protein-clearing system for the brain. To analyze the modes of mass transfer in the PVS, a digitized scan of a mouse brain PVS segment was meshed and used for computational fluid dynamics (CFD) studies. Tandem analyses were then carried out and compared between the mouse PVS section and a cylinder with commensurate dimensionless parameters and hydraulic resistance. The geometry pair was used to first validate the CFD model and then assess mass transfer in various advection states: no-flow, constant flow, sinusoidal flow, sinusoidal flow with zero net solvent flux, and an anatomically correct asymmetrical periodic flow. Two mass transfer situations were considered, one being a protein build-up and the other being a protein blend-down using a multitude of metrics. Bulk arterial solute transport was found to be advection-controlled. The consideration of temporal evolution and trajectories of contiguous protein bolus volumes revealed that flow pulsation was beneficial at bolus break-up and that additional local wall curvature-based geometry irregularities also were. Using certain measures, local solute peak concentration blend-down appeared to be diffusion-dominated even for high Peclet numbers; however, bolus size evolution analyses showed definite advection support.
publisherThe American Society of Mechanical Engineers (ASME)
titleHow Irregular Geometry and Flow Waveform Affect Pulsating Arterial Mass Transfer
typeJournal Paper
journal volume146
journal issue12
journal titleJournal of Biomechanical Engineering
identifier doi10.1115/1.4065556
journal fristpage121011-1
journal lastpage121011-12
page12
treeJournal of Biomechanical Engineering:;2024:;volume( 146 ):;issue: 012
contenttypeFulltext


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