Atherosclerotic Calcifications Have a Local Effect on the Peel Behavior of Human Aortic MediaSource: Journal of Biomechanical Engineering:;2024:;volume( 146 ):;issue: 006::page 61003-1Author:Donahue, Carly L.
,
Badal, Ruturaj M.
,
Younger, Thomas S.
,
Guan, Weihua
,
Tolkacheva, Elena G.
,
Barocas, Victor H.
DOI: 10.1115/1.4064682Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Aortic dissections, characterized by the propagation of a tear through the layers of the vessel wall, are critical, life-threatening events. Aortic calcifications are a common comorbidity in both acute and chronic dissections, yet their impact on dissection mechanics remains unclear. Using micro-computed tomography (CT) imaging, peel testing, and finite element modeling, this study examines the interplay between atherosclerotic calcifications and dissection mechanics. Samples cut from cadaveric human thoracic aortas were micro-CT imaged and subsequently peel-tested to map peel tension curves to the location of aortic calcifications. Empirical mode decomposition separated peel tension curves into high and low-frequency components, with high-frequency effects corresponding to interlamellar bonding mechanics and low-frequency effects to peel tension fluctuations. Finally, we used an idealized finite element model to examine how stiff calcifications affect aortic failure mechanics. Results showed that atherosclerosis influences dissection behavior on multiple length scales. Experimentally, atherosclerotic samples exhibited higher peel tensions and greater variance in the axial direction. The variation was driven by increased amplitudes of low-frequency tension fluctuations in diseased samples, indicating that more catastrophic propagations occur near calcifications. The simulations corroborated this finding, suggesting that the low-frequency changes resulted from the presence of a stiff calcification in the vessel wall. There were also modifications to the high-frequency peel mechanics, a response likely attributable to alterations in the microstructure and interlamellar bonding within the media. Considered collectively, these findings demonstrate that dissection mechanics are modified in aortic media nearby and adjacent to aortic calcifications.
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contributor author | Donahue, Carly L. | |
contributor author | Badal, Ruturaj M. | |
contributor author | Younger, Thomas S. | |
contributor author | Guan, Weihua | |
contributor author | Tolkacheva, Elena G. | |
contributor author | Barocas, Victor H. | |
date accessioned | 2024-04-24T22:40:14Z | |
date available | 2024-04-24T22:40:14Z | |
date copyright | 3/25/2024 12:00:00 AM | |
date issued | 2024 | |
identifier issn | 0148-0731 | |
identifier other | bio_146_06_061003.pdf | |
identifier uri | http://yetl.yabesh.ir/yetl1/handle/yetl/4295653 | |
description abstract | Aortic dissections, characterized by the propagation of a tear through the layers of the vessel wall, are critical, life-threatening events. Aortic calcifications are a common comorbidity in both acute and chronic dissections, yet their impact on dissection mechanics remains unclear. Using micro-computed tomography (CT) imaging, peel testing, and finite element modeling, this study examines the interplay between atherosclerotic calcifications and dissection mechanics. Samples cut from cadaveric human thoracic aortas were micro-CT imaged and subsequently peel-tested to map peel tension curves to the location of aortic calcifications. Empirical mode decomposition separated peel tension curves into high and low-frequency components, with high-frequency effects corresponding to interlamellar bonding mechanics and low-frequency effects to peel tension fluctuations. Finally, we used an idealized finite element model to examine how stiff calcifications affect aortic failure mechanics. Results showed that atherosclerosis influences dissection behavior on multiple length scales. Experimentally, atherosclerotic samples exhibited higher peel tensions and greater variance in the axial direction. The variation was driven by increased amplitudes of low-frequency tension fluctuations in diseased samples, indicating that more catastrophic propagations occur near calcifications. The simulations corroborated this finding, suggesting that the low-frequency changes resulted from the presence of a stiff calcification in the vessel wall. There were also modifications to the high-frequency peel mechanics, a response likely attributable to alterations in the microstructure and interlamellar bonding within the media. Considered collectively, these findings demonstrate that dissection mechanics are modified in aortic media nearby and adjacent to aortic calcifications. | |
publisher | The American Society of Mechanical Engineers (ASME) | |
title | Atherosclerotic Calcifications Have a Local Effect on the Peel Behavior of Human Aortic Media | |
type | Journal Paper | |
journal volume | 146 | |
journal issue | 6 | |
journal title | Journal of Biomechanical Engineering | |
identifier doi | 10.1115/1.4064682 | |
journal fristpage | 61003-1 | |
journal lastpage | 61003-13 | |
page | 13 | |
tree | Journal of Biomechanical Engineering:;2024:;volume( 146 ):;issue: 006 | |
contenttype | Fulltext |