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    Mechanical Deformation of Peripapillary Retina in Response to Acute Intraocular Pressure Elevation

    Source: Journal of Biomechanical Engineering:;2022:;volume( 144 ):;issue: 006::page 61001-1
    Author:
    Kwok, Sunny
    ,
    Pan, Manqi
    ,
    Hazen, Nicholas
    ,
    Pan, Xueliang
    ,
    Liu, Jun
    DOI: 10.1115/1.4053450
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Elevated intraocular pressure (IOP) may cause mechanical injuries to the optic nerve head (ONH) and the peripapillary tissues in glaucoma. Previous studies have reported the mechanical deformation of the ONH and the peripapillary sclera (PPS) at elevated IOP. The deformation of the peripapillary retina (PPR) has not been well-characterized. Here we applied high-frequency ultrasound elastography to map and quantify PPR deformation, and compared PPR, PPS and ONH deformation in the same eye. Whole globe inflation was performed in ten human donor eyes. High-frequency ultrasound scans of the posterior eye were acquired while IOP was raised from 5 to 30 mmHg. A correlation-based ultrasound speckle tracking algorithm was used to compute pressure-induced displacements within the scanned tissue cross sections. Radial, tangential, and shear strains were calculated for the PPR, PPS, and ONH regions. In PPR, shear was significantly larger in magnitude than radial and tangential strains. Strain maps showed localized high shear and high tangential strains in PPR. In comparison to PPS and ONH, PPR had greater shear and a similar level of tangential strain. Surprisingly, PPR radial compression was minimal and significantly smaller than that in PPS. These results provide new insights into PPR deformation in response of IOP elevation, suggesting that shear rather than compression was likely the primary mode of IOP-induced mechanical insult in PPR. High shear, especially localized high shear, may contribute to the mechanical damage of this tissue in glaucoma.
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      Mechanical Deformation of Peripapillary Retina in Response to Acute Intraocular Pressure Elevation

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    contributor authorKwok, Sunny
    contributor authorPan, Manqi
    contributor authorHazen, Nicholas
    contributor authorPan, Xueliang
    contributor authorLiu, Jun
    date accessioned2022-05-08T09:37:07Z
    date available2022-05-08T09:37:07Z
    date copyright2/15/2022 12:00:00 AM
    date issued2022
    identifier issn0148-0731
    identifier otherbio_144_06_061001.pdf
    identifier urihttp://yetl.yabesh.ir/yetl1/handle/yetl/4285363
    description abstractElevated intraocular pressure (IOP) may cause mechanical injuries to the optic nerve head (ONH) and the peripapillary tissues in glaucoma. Previous studies have reported the mechanical deformation of the ONH and the peripapillary sclera (PPS) at elevated IOP. The deformation of the peripapillary retina (PPR) has not been well-characterized. Here we applied high-frequency ultrasound elastography to map and quantify PPR deformation, and compared PPR, PPS and ONH deformation in the same eye. Whole globe inflation was performed in ten human donor eyes. High-frequency ultrasound scans of the posterior eye were acquired while IOP was raised from 5 to 30 mmHg. A correlation-based ultrasound speckle tracking algorithm was used to compute pressure-induced displacements within the scanned tissue cross sections. Radial, tangential, and shear strains were calculated for the PPR, PPS, and ONH regions. In PPR, shear was significantly larger in magnitude than radial and tangential strains. Strain maps showed localized high shear and high tangential strains in PPR. In comparison to PPS and ONH, PPR had greater shear and a similar level of tangential strain. Surprisingly, PPR radial compression was minimal and significantly smaller than that in PPS. These results provide new insights into PPR deformation in response of IOP elevation, suggesting that shear rather than compression was likely the primary mode of IOP-induced mechanical insult in PPR. High shear, especially localized high shear, may contribute to the mechanical damage of this tissue in glaucoma.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleMechanical Deformation of Peripapillary Retina in Response to Acute Intraocular Pressure Elevation
    typeJournal Paper
    journal volume144
    journal issue6
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.4053450
    journal fristpage61001-1
    journal lastpage61001-6
    page6
    treeJournal of Biomechanical Engineering:;2022:;volume( 144 ):;issue: 006
    contenttypeFulltext
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