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contributor authorBodnyk, Kyle A.
contributor authorKim, Do-Gyoon
contributor authorPan, Xueliang
contributor authorHart, Richard T.
date accessioned2022-05-08T09:24:12Z
date available2022-05-08T09:24:12Z
date copyright12/17/2021 12:00:00 AM
date issued2021
identifier issn0148-0731
identifier otherbio_144_04_041010.pdf
identifier urihttp://yetl.yabesh.ir/yetl1/handle/yetl/4285097
description abstractAs an alternative to drug treatments, low-magnitude mechanical stimulation (LMMS) may improve skeletal health without potential side effects from drugs. LMMS has been shown to increase bone health short term in both animal and clinical studies. Long-term changes to the mechanical properties of bone from LMMS are currently unknown, so the objective of this research was to establish the methodology and preliminary results for investigating the long-term effects of whole body vibration therapy on the elastic and viscoelastic properties of bone. In this study, 10-week-old female BALB/cByJ mice were given LMMS (15 min/day, 5 days/week, 0.3 g, 90 Hz) for 8 weeks
description abstractSHAM did not receive LMMS. Two sets of groups remained on study for an additional 8 or 16 weeks post-LMMS (N = 17). Micro-CT and fluorochrome histomorphology of these femurs were studied and results were published by Bodnyk et al. (2020, “The Long-Term Residual Effects of Low-Magnitude Mechanical Stimulation Therapy on Skeletal Health,” J. Biol. Eng., 14, Article No. 9.). Femoral quasi-static bending stiffness trended 4.2% increase in stiffness after 8 weeks of LMMS and 1.3% increase 8 weeks post-LMMS compared to SHAM. Damping, tan delta, and loss stiffness significantly increased by 17.6%, 16.3%, and 16.6%, respectively, at 8 weeks LMMS compared to SHAM. Finite element models of applied LMMS signal showed decreased stress in the mid-diaphyseal region at both 8-week LMMS and 8-week post-LMMS compared to SHAM. Residual mechanical changes in bone during and post-LMMS indicate that LMMS could be used to increase long-term mechanical integrity of bone.
publisherThe American Society of Mechanical Engineers (ASME)
titleThe Long-Term Residual Effects of Low-Magnitude Mechanical Stimulation on Murine Femoral Mechanics
typeJournal Paper
journal volume144
journal issue4
journal titleJournal of Biomechanical Engineering
identifier doi10.1115/1.4053101
journal fristpage41010-1
journal lastpage41010-10
page10
treeJournal of Biomechanical Engineering:;2021:;volume( 144 ):;issue: 004
contenttypeFulltext


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