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    Collagen Fibril Orientation in Tissue Specimens From Atherosclerotic Plaque Explored Using Small Angle X-Ray Scattering

    Source: Journal of Biomechanical Engineering:;2021:;volume( 144 ):;issue: 002::page 24505-1
    Author:
    Silva, Herbert
    ,
    Tassone, Christopher
    ,
    Ross, Elsie Gyang
    ,
    Lee, Jason T.
    ,
    Zhou, Wei
    ,
    Nelson, Drew
    DOI: 10.1115/1.4052432
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Atherosclerotic plaques can gradually develop in certain arteries. Disruption of fibrous tissue in plaques can result in plaque rupture and thromboembolism, leading to heart attacks and strokes. Collagen fibrils are important tissue building blocks and tissue strength depends on how fibrils are oriented. Fibril orientation in plaque tissue may potentially influence vulnerability to disruption. While X-ray scattering has previously been used to characterize fibril orientations in soft tissues and bones, it has never been used for characterization of human atherosclerotic plaque tissue. This study served to explore fibril orientation in specimens from human plaques using small angle X-ray scattering (SAXS). Plaque tissue was extracted from human femoral and carotid arteries, and each tissue specimen contained a region of calcified material. Three-dimensional (3D) collagen fibril orientation was determined along scan lines that started away from and then extended toward a given calcification. Fibrils were found to be oriented mainly in the circumferential direction of the plaque tissue at the majority of locations away from calcifications. However, in a number of cases, the dominant fibril direction differed near a calcification, changing from circumferential to longitudinal or thickness (radial) directions. Further study is needed to elucidate how these fibril orientations may influence plaque tissue stress–strain behavior and vulnerability to rupture.
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      Collagen Fibril Orientation in Tissue Specimens From Atherosclerotic Plaque Explored Using Small Angle X-Ray Scattering

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    http://yetl.yabesh.ir/yetl1/handle/yetl/4284841
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    contributor authorSilva, Herbert
    contributor authorTassone, Christopher
    contributor authorRoss, Elsie Gyang
    contributor authorLee, Jason T.
    contributor authorZhou, Wei
    contributor authorNelson, Drew
    date accessioned2022-05-08T09:11:41Z
    date available2022-05-08T09:11:41Z
    date copyright12/1/2021 12:00:00 AM
    date issued2021
    identifier issn0148-0731
    identifier otherbio_144_02_024505.pdf
    identifier urihttp://yetl.yabesh.ir/yetl1/handle/yetl/4284841
    description abstractAtherosclerotic plaques can gradually develop in certain arteries. Disruption of fibrous tissue in plaques can result in plaque rupture and thromboembolism, leading to heart attacks and strokes. Collagen fibrils are important tissue building blocks and tissue strength depends on how fibrils are oriented. Fibril orientation in plaque tissue may potentially influence vulnerability to disruption. While X-ray scattering has previously been used to characterize fibril orientations in soft tissues and bones, it has never been used for characterization of human atherosclerotic plaque tissue. This study served to explore fibril orientation in specimens from human plaques using small angle X-ray scattering (SAXS). Plaque tissue was extracted from human femoral and carotid arteries, and each tissue specimen contained a region of calcified material. Three-dimensional (3D) collagen fibril orientation was determined along scan lines that started away from and then extended toward a given calcification. Fibrils were found to be oriented mainly in the circumferential direction of the plaque tissue at the majority of locations away from calcifications. However, in a number of cases, the dominant fibril direction differed near a calcification, changing from circumferential to longitudinal or thickness (radial) directions. Further study is needed to elucidate how these fibril orientations may influence plaque tissue stress–strain behavior and vulnerability to rupture.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleCollagen Fibril Orientation in Tissue Specimens From Atherosclerotic Plaque Explored Using Small Angle X-Ray Scattering
    typeJournal Paper
    journal volume144
    journal issue2
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.4052432
    journal fristpage24505-1
    journal lastpage24505-8
    page8
    treeJournal of Biomechanical Engineering:;2021:;volume( 144 ):;issue: 002
    contenttypeFulltext
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    DSpace software copyright © 2002-2015  DuraSpace
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