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    Flow Dynamics in the Aortic Arch and Its Effect on the Arterial Input Function in Cardiac Computed Tomography

    Source: Journal of Biomechanical Engineering:;2019:;volume( 141 ):;issue: 010::page 104501
    Author:
    Eslami, Parastou
    ,
    Seo, Jung-Hee
    ,
    Lardo, Albert C.
    ,
    Chen, Marcus Y.
    ,
    Mittal, Rajat
    DOI: 10.1115/1.4043076
    Publisher: American Society of Mechanical Engineers (ASME)
    Abstract: The arterial input function (AIF)—time-density curve (TDC) of contrast at the coronary ostia—plays a central role in contrast enhanced computed tomography angiography (CTA). This study employs computational modeling in a patient-specific aorta to investigate mixing and dispersion of contrast in the aortic arch (AA) and to compare the TDCs in the coronary ostium and the descending aorta. Here, we examine the validity of the use of TDC in the descending aorta as a surrogate for the AIF. Computational fluid dynamics (CFD) was used to study hemodynamics and contrast dispersion in a CTA-based patient model of the aorta. Variations in TDC between the aortic root, through the AA and at the descending aorta and the effect of flow patterns on contrast dispersion was studied via postprocessing of the results. Simulations showed complex unsteady patterns of contrast mixing and dispersion in the AA that are driven by the pulsatile flow. However, despite the relatively long intra-aortic distance between the coronary ostia and the descending aorta, the TDCs at these two locations were similar in terms of rise-time and up-slope, and the time lag between the two TDCs was 0.19 s. TDC in the descending aorta is an accurate analog of the AIF. Methods that use quantitative metrics such as rise-time and slope of the AIF to estimate coronary flowrate and myocardial ischemia can continue with the current practice of using the TDC at the descending aorta as a surrogate for the AIF.
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      Flow Dynamics in the Aortic Arch and Its Effect on the Arterial Input Function in Cardiac Computed Tomography

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    contributor authorEslami, Parastou
    contributor authorSeo, Jung-Hee
    contributor authorLardo, Albert C.
    contributor authorChen, Marcus Y.
    contributor authorMittal, Rajat
    date accessioned2019-09-18T09:06:20Z
    date available2019-09-18T09:06:20Z
    date copyright7/15/2019 12:00:00 AM
    date issued2019
    identifier issn0148-0731
    identifier otherbio_141_10_104501
    identifier urihttp://yetl.yabesh.ir/yetl1/handle/yetl/4258910
    description abstractThe arterial input function (AIF)—time-density curve (TDC) of contrast at the coronary ostia—plays a central role in contrast enhanced computed tomography angiography (CTA). This study employs computational modeling in a patient-specific aorta to investigate mixing and dispersion of contrast in the aortic arch (AA) and to compare the TDCs in the coronary ostium and the descending aorta. Here, we examine the validity of the use of TDC in the descending aorta as a surrogate for the AIF. Computational fluid dynamics (CFD) was used to study hemodynamics and contrast dispersion in a CTA-based patient model of the aorta. Variations in TDC between the aortic root, through the AA and at the descending aorta and the effect of flow patterns on contrast dispersion was studied via postprocessing of the results. Simulations showed complex unsteady patterns of contrast mixing and dispersion in the AA that are driven by the pulsatile flow. However, despite the relatively long intra-aortic distance between the coronary ostia and the descending aorta, the TDCs at these two locations were similar in terms of rise-time and up-slope, and the time lag between the two TDCs was 0.19 s. TDC in the descending aorta is an accurate analog of the AIF. Methods that use quantitative metrics such as rise-time and slope of the AIF to estimate coronary flowrate and myocardial ischemia can continue with the current practice of using the TDC at the descending aorta as a surrogate for the AIF.
    publisherAmerican Society of Mechanical Engineers (ASME)
    titleFlow Dynamics in the Aortic Arch and Its Effect on the Arterial Input Function in Cardiac Computed Tomography
    typeJournal Paper
    journal volume141
    journal issue10
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.4043076
    journal fristpage104501
    journal lastpage104501-8
    treeJournal of Biomechanical Engineering:;2019:;volume( 141 ):;issue: 010
    contenttypeFulltext
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    DSpace software copyright © 2002-2015  DuraSpace
    نرم افزار کتابخانه دیجیتال "دی اسپیس" فارسی شده توسط یابش برای کتابخانه های ایرانی | تماس با یابش
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