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    Differential Effects of Isoproterenol on Regional Myocardial Mechanics in Rat Using Three-Dimensional Cine DENSE Cardiovascular Magnetic Resonance

    Source: Journal of Biomechanical Engineering:;2019:;volume( 141 ):;issue: 006::page 60904
    Author:
    Zhang, Xiaoyan
    ,
    Liu, Zhan-Qiu
    ,
    Singh, Dara
    ,
    Powell, David K.
    ,
    Chung, Charles S.
    ,
    Campbell, Kenneth S.
    ,
    Wenk, Jonathan F.
    DOI: 10.1115/1.4041042
    Publisher: American Society of Mechanical Engineers (ASME)
    Abstract: The present study assessed the acute effects of isoproterenol on left ventricular (LV) mechanics in healthy rats with the hypothesis that β-adrenergic stimulation influences the mechanics of different myocardial regions of the LV wall in different ways. To accomplish this, magnetic resonance images were obtained in the LV of healthy rats with or without isoproterenol infusion. The LV contours were divided into basal, midventricular, and apical regions. Additionally, the midventricular myocardium was divided into three transmural layers with each layer partitioned into four segments (i.e., septal, inferior, lateral, and anterior). Peak systolic strains and torsion were quantified for each region. Isoproterenol significantly increased peak systolic radial strain and circumferential-longitudinal (CL) shear strain, as well as ventricular torsion, throughout the basal, midventricle, and apical regions. In the midventricle, isoproterenol significantly increased peak systolic radial strain, and induced significant increases in peak systolic circumferential strain and longitudinal strain in the septum. Isoproterenol consistently increased peak systolic CL shear strain in all midventricular segments. Ventricular torsion was significantly increased in nearly all segments except the inferior subendocardium. The effects of isoproterenol on LV systolic mechanics (i.e., three-dimensional (3D) strains and torsion) in healthy rats depend on the region. This region dependency is also strain component-specific. These results provide insight into the regional response of LV mechanics to β-adrenergic stimulation in rats and could act as a baseline for future studies on subclinical abnormalities associated with the inotropic response in heart disease.
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      Differential Effects of Isoproterenol on Regional Myocardial Mechanics in Rat Using Three-Dimensional Cine DENSE Cardiovascular Magnetic Resonance

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    contributor authorZhang, Xiaoyan
    contributor authorLiu, Zhan-Qiu
    contributor authorSingh, Dara
    contributor authorPowell, David K.
    contributor authorChung, Charles S.
    contributor authorCampbell, Kenneth S.
    contributor authorWenk, Jonathan F.
    date accessioned2019-09-18T09:05:31Z
    date available2019-09-18T09:05:31Z
    date copyright4/22/2019 12:00:00 AM
    date issued2019
    identifier issn0148-0731
    identifier otherbio_141_06_060904
    identifier urihttp://yetl.yabesh.ir/yetl1/handle/yetl/4258755
    description abstractThe present study assessed the acute effects of isoproterenol on left ventricular (LV) mechanics in healthy rats with the hypothesis that β-adrenergic stimulation influences the mechanics of different myocardial regions of the LV wall in different ways. To accomplish this, magnetic resonance images were obtained in the LV of healthy rats with or without isoproterenol infusion. The LV contours were divided into basal, midventricular, and apical regions. Additionally, the midventricular myocardium was divided into three transmural layers with each layer partitioned into four segments (i.e., septal, inferior, lateral, and anterior). Peak systolic strains and torsion were quantified for each region. Isoproterenol significantly increased peak systolic radial strain and circumferential-longitudinal (CL) shear strain, as well as ventricular torsion, throughout the basal, midventricle, and apical regions. In the midventricle, isoproterenol significantly increased peak systolic radial strain, and induced significant increases in peak systolic circumferential strain and longitudinal strain in the septum. Isoproterenol consistently increased peak systolic CL shear strain in all midventricular segments. Ventricular torsion was significantly increased in nearly all segments except the inferior subendocardium. The effects of isoproterenol on LV systolic mechanics (i.e., three-dimensional (3D) strains and torsion) in healthy rats depend on the region. This region dependency is also strain component-specific. These results provide insight into the regional response of LV mechanics to β-adrenergic stimulation in rats and could act as a baseline for future studies on subclinical abnormalities associated with the inotropic response in heart disease.
    publisherAmerican Society of Mechanical Engineers (ASME)
    titleDifferential Effects of Isoproterenol on Regional Myocardial Mechanics in Rat Using Three-Dimensional Cine DENSE Cardiovascular Magnetic Resonance
    typeJournal Paper
    journal volume141
    journal issue6
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.4041042
    journal fristpage60904
    journal lastpage060904-9
    treeJournal of Biomechanical Engineering:;2019:;volume( 141 ):;issue: 006
    contenttypeFulltext
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    DSpace software copyright © 2002-2015  DuraSpace
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