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    On the Relative Impact of Intraluminal Thrombus Heterogeneity on Abdominal Aortic Aneurysm Mechanics

    Source: Journal of Biomechanical Engineering:;2019:;volume( 141 ):;issue: 011::page 111010
    Author:
    Leach, Joseph R.
    ,
    Kao, Evan
    ,
    Zhu, Chengcheng
    ,
    Saloner, David
    ,
    Hope, Michael D.
    DOI: 10.1115/1.4044143
    Publisher: American Society of Mechanical Engineers (ASME)
    Abstract: Intraluminal thrombus (ILT) is present in the majority of abdominal aortic aneurysms (AAA) of a size warranting consideration for surgical or endovascular intervention. The rupture risk of AAAs is thought to be related to the balance of vessel wall strength and the mechanical stress caused by systemic blood pressure. Previous finite element analyses of AAAs have shown that ILT can reduce and homogenize aneurysm wall stress. These works have largely considered ILT to be homogeneous in mechanical character or have idealized a stiffness distribution through the thrombus thickness. In this work, we use magnetic resonance imaging (MRI) to delineate the heterogeneous composition of ILT in 7 AAAs and perform patient–specific finite element analysis under multiple conditions of ILT layer stiffness disparity. We find that explicit incorporation of ILT heterogeneity in the finite element analysis is unlikely to substantially alter major stress analysis predictions regarding aneurysm rupture risk in comparison to models assuming a homogenous thrombus, provided that the maximal ILT stiffness is the same between models. Our results also show that under a homogeneous ILT assumption, the choice of ILT stiffness from values common in the literature can result in significantly larger variations in stress predictions compared to the effects of thrombus heterogeneity.
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      On the Relative Impact of Intraluminal Thrombus Heterogeneity on Abdominal Aortic Aneurysm Mechanics

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    contributor authorLeach, Joseph R.
    contributor authorKao, Evan
    contributor authorZhu, Chengcheng
    contributor authorSaloner, David
    contributor authorHope, Michael D.
    date accessioned2019-09-18T09:03:25Z
    date available2019-09-18T09:03:25Z
    date copyright7/31/2019 12:00:00 AM
    date issued2019
    identifier issn0148-0731
    identifier otherbio_141_11_111010
    identifier urihttp://yetl.yabesh.ir/yetl1/handle/yetl/4258343
    description abstractIntraluminal thrombus (ILT) is present in the majority of abdominal aortic aneurysms (AAA) of a size warranting consideration for surgical or endovascular intervention. The rupture risk of AAAs is thought to be related to the balance of vessel wall strength and the mechanical stress caused by systemic blood pressure. Previous finite element analyses of AAAs have shown that ILT can reduce and homogenize aneurysm wall stress. These works have largely considered ILT to be homogeneous in mechanical character or have idealized a stiffness distribution through the thrombus thickness. In this work, we use magnetic resonance imaging (MRI) to delineate the heterogeneous composition of ILT in 7 AAAs and perform patient–specific finite element analysis under multiple conditions of ILT layer stiffness disparity. We find that explicit incorporation of ILT heterogeneity in the finite element analysis is unlikely to substantially alter major stress analysis predictions regarding aneurysm rupture risk in comparison to models assuming a homogenous thrombus, provided that the maximal ILT stiffness is the same between models. Our results also show that under a homogeneous ILT assumption, the choice of ILT stiffness from values common in the literature can result in significantly larger variations in stress predictions compared to the effects of thrombus heterogeneity.
    publisherAmerican Society of Mechanical Engineers (ASME)
    titleOn the Relative Impact of Intraluminal Thrombus Heterogeneity on Abdominal Aortic Aneurysm Mechanics
    typeJournal Paper
    journal volume141
    journal issue11
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.4044143
    journal fristpage111010
    journal lastpage111010-10
    treeJournal of Biomechanical Engineering:;2019:;volume( 141 ):;issue: 011
    contenttypeFulltext
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    نرم افزار کتابخانه دیجیتال "دی اسپیس" فارسی شده توسط یابش برای کتابخانه های ایرانی | تماس با یابش
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