contributor author | Leach, Joseph R. | |
contributor author | Kao, Evan | |
contributor author | Zhu, Chengcheng | |
contributor author | Saloner, David | |
contributor author | Hope, Michael D. | |
date accessioned | 2019-09-18T09:03:25Z | |
date available | 2019-09-18T09:03:25Z | |
date copyright | 7/31/2019 12:00:00 AM | |
date issued | 2019 | |
identifier issn | 0148-0731 | |
identifier other | bio_141_11_111010 | |
identifier uri | http://yetl.yabesh.ir/yetl1/handle/yetl/4258343 | |
description abstract | Intraluminal thrombus (ILT) is present in the majority of abdominal aortic aneurysms (AAA) of a size warranting consideration for surgical or endovascular intervention. The rupture risk of AAAs is thought to be related to the balance of vessel wall strength and the mechanical stress caused by systemic blood pressure. Previous finite element analyses of AAAs have shown that ILT can reduce and homogenize aneurysm wall stress. These works have largely considered ILT to be homogeneous in mechanical character or have idealized a stiffness distribution through the thrombus thickness. In this work, we use magnetic resonance imaging (MRI) to delineate the heterogeneous composition of ILT in 7 AAAs and perform patient–specific finite element analysis under multiple conditions of ILT layer stiffness disparity. We find that explicit incorporation of ILT heterogeneity in the finite element analysis is unlikely to substantially alter major stress analysis predictions regarding aneurysm rupture risk in comparison to models assuming a homogenous thrombus, provided that the maximal ILT stiffness is the same between models. Our results also show that under a homogeneous ILT assumption, the choice of ILT stiffness from values common in the literature can result in significantly larger variations in stress predictions compared to the effects of thrombus heterogeneity. | |
publisher | American Society of Mechanical Engineers (ASME) | |
title | On the Relative Impact of Intraluminal Thrombus Heterogeneity on Abdominal Aortic Aneurysm Mechanics | |
type | Journal Paper | |
journal volume | 141 | |
journal issue | 11 | |
journal title | Journal of Biomechanical Engineering | |
identifier doi | 10.1115/1.4044143 | |
journal fristpage | 111010 | |
journal lastpage | 111010-10 | |
tree | Journal of Biomechanical Engineering:;2019:;volume( 141 ):;issue: 011 | |
contenttype | Fulltext | |