| contributor author | Bahwini, Tariq Mohana | |
| contributor author | Zhong, Yongmin | |
| contributor author | Gu, Chengfan | |
| contributor author | Nasa, Zeyad | |
| contributor author | Oetomo, Denny | |
| date accessioned | 2019-02-28T11:04:44Z | |
| date available | 2019-02-28T11:04:44Z | |
| date copyright | 10/8/2018 12:00:00 AM | |
| date issued | 2018 | |
| identifier issn | 1932-6181 | |
| identifier other | med_012_04_041007.pdf | |
| identifier uri | http://yetl.yabesh.ir/yetl1/handle/yetl/4252439 | |
| description abstract | Characterization of cell mechanical properties plays an important role in disease diagnoses and treatments. This paper uses advanced atomic force microscopy (AFM) to measure the geometrical and mechanical properties of two different human brain normal HNC-2 and cancer U87 MG cells. Based on experimental measurement, it measures the cell deformation and indentation force to characterize cell mechanical properties. A fitting algorithm is developed to generate the force-loading curves from experimental data. An inverse Hertzian method is also established to identify Young's moduli for HNC-2 and U87 MG cells. The results demonstrate that Young's modulus of cancer cells is different from that of normal cells, which can help us to differentiate normal and cancer cells from the biomechanical viewpoint. | |
| publisher | The American Society of Mechanical Engineers (ASME) | |
| title | Investigating the Mechanical Properties of Biological Brain Cells With Atomic Force Microscopy | |
| type | Journal Paper | |
| journal volume | 12 | |
| journal issue | 4 | |
| journal title | Journal of Medical Devices | |
| identifier doi | 10.1115/1.4040995 | |
| journal fristpage | 41007 | |
| journal lastpage | 041007-12 | |
| tree | Journal of Medical Devices:;2018:;volume( 012 ):;issue: 004 | |
| contenttype | Fulltext | |