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    Design and Fabrication of a Three-Dimensional Multi-Electrode Array for Neuron Electrophysiology

    Source: Journal of Biomechanical Engineering:;2017:;volume( 139 ):;issue: 012::page 121011
    Author:
    Zuo
    ,
    Lei;Yu
    ,
    Shifeng;Briggs
    ,
    Clark A.;Kantor
    ,
    Stanislaw;Pan
    ,
    Jeffery Y.
    DOI: 10.1115/1.4037948
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Neural recording and stimulation with high spatial and temporal resolution are highly desirable in the study of neurocommunication and diseases. Planar multiple microelectrode arrays (MEA) or quasi-three-dimensional (3D) MEA with fixed height have been proposed by many researchers and become commercially available. In this paper, we present the design, fabrication, and test of a novel true 3D multiple electrode array for brain slice stimulation and recording. This MEA is composed of 105 microelectrodes with 50 μm diameter and 125 μm center-to-center spacing integrated in a 1.2 × 1.2 mm2 area. This “true” 3D MEA allows us to precisely position the individual electrodes by piezoelectric-based actuators to penetrate the inactive tissue layer and to approach the active neurons so as to optimize the recording and stimulation of electrical field potential. The capability to stimulate nerve fibers and record postsynaptic field potentials was demonstrated in an experiment using mouse brain hippocampus slice.
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      Design and Fabrication of a Three-Dimensional Multi-Electrode Array for Neuron Electrophysiology

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    http://yetl.yabesh.ir/yetl1/handle/yetl/4242948
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    contributor authorZuo
    contributor authorLei;Yu
    contributor authorShifeng;Briggs
    contributor authorClark A.;Kantor
    contributor authorStanislaw;Pan
    contributor authorJeffery Y.
    date accessioned2017-12-30T11:43:57Z
    date available2017-12-30T11:43:57Z
    date copyright10/3/2017 12:00:00 AM
    date issued2017
    identifier issn0148-0731
    identifier otherbio_139_12_121011.pdf
    identifier urihttp://138.201.223.254:8080/yetl1/handle/yetl/4242948
    description abstractNeural recording and stimulation with high spatial and temporal resolution are highly desirable in the study of neurocommunication and diseases. Planar multiple microelectrode arrays (MEA) or quasi-three-dimensional (3D) MEA with fixed height have been proposed by many researchers and become commercially available. In this paper, we present the design, fabrication, and test of a novel true 3D multiple electrode array for brain slice stimulation and recording. This MEA is composed of 105 microelectrodes with 50 μm diameter and 125 μm center-to-center spacing integrated in a 1.2 × 1.2 mm2 area. This “true” 3D MEA allows us to precisely position the individual electrodes by piezoelectric-based actuators to penetrate the inactive tissue layer and to approach the active neurons so as to optimize the recording and stimulation of electrical field potential. The capability to stimulate nerve fibers and record postsynaptic field potentials was demonstrated in an experiment using mouse brain hippocampus slice.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleDesign and Fabrication of a Three-Dimensional Multi-Electrode Array for Neuron Electrophysiology
    typeJournal Paper
    journal volume139
    journal issue12
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.4037948
    journal fristpage121011
    journal lastpage121011-6
    treeJournal of Biomechanical Engineering:;2017:;volume( 139 ):;issue: 012
    contenttypeFulltext
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    DSpace software copyright © 2002-2015  DuraSpace
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