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    Failure of the Porcine Ascending Aorta: Multidirectional Experiments and a Unifying Microstructural Model

    Source: Journal of Biomechanical Engineering:;2017:;volume( 139 ):;issue: 003::page 31005
    Author:
    Witzenburg, Colleen M.
    ,
    Dhume, Rohit Y.
    ,
    Shah, Sachin B.
    ,
    Korenczuk, Christopher E.
    ,
    Wagner, Hallie P.
    ,
    Alford, Patrick W.
    ,
    Barocas, Victor H.
    DOI: 10.1115/1.4035264
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: The ascending thoracic aorta is poorly understood mechanically, especially its risk of dissection. To make better predictions of dissection risk, more information about the multidimensional failure behavior of the tissue is needed, and this information must be incorporated into an appropriate theoretical/computational model. Toward the creation of such a model, uniaxial, equibiaxial, peel, and shear lap tests were performed on healthy porcine ascending aorta samples. Uniaxial and equibiaxial tests showed anisotropy with greater stiffness and strength in the circumferential direction. Shear lap tests showed catastrophic failure at shear stresses (150–200 kPa) much lower than uniaxial tests (750–2500 kPa), consistent with the low peel tension (∼60 mN/mm). A novel multiscale computational model, including both prefailure and failure mechanics of the aorta, was developed. The microstructural part of the model included contributions from a collagen-reinforced elastin sheet and interlamellar connections representing fibrillin and smooth muscle. Components were represented as nonlinear fibers that failed at a critical stretch. Multiscale simulations of the different experiments were performed, and the model, appropriately specified, agreed well with all experimental data, representing a uniquely complete structure-based description of aorta mechanics. In addition, our experiments and model demonstrate the very low strength of the aorta in radial shear, suggesting an important possible mechanism for aortic dissection.
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      Failure of the Porcine Ascending Aorta: Multidirectional Experiments and a Unifying Microstructural Model

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    contributor authorWitzenburg, Colleen M.
    contributor authorDhume, Rohit Y.
    contributor authorShah, Sachin B.
    contributor authorKorenczuk, Christopher E.
    contributor authorWagner, Hallie P.
    contributor authorAlford, Patrick W.
    contributor authorBarocas, Victor H.
    date accessioned2017-11-25T07:18:46Z
    date available2017-11-25T07:18:46Z
    date copyright2017/23/1
    date issued2017
    identifier issn0148-0731
    identifier otherbio_139_03_031005.pdf
    identifier urihttp://138.201.223.254:8080/yetl1/handle/yetl/4235397
    description abstractThe ascending thoracic aorta is poorly understood mechanically, especially its risk of dissection. To make better predictions of dissection risk, more information about the multidimensional failure behavior of the tissue is needed, and this information must be incorporated into an appropriate theoretical/computational model. Toward the creation of such a model, uniaxial, equibiaxial, peel, and shear lap tests were performed on healthy porcine ascending aorta samples. Uniaxial and equibiaxial tests showed anisotropy with greater stiffness and strength in the circumferential direction. Shear lap tests showed catastrophic failure at shear stresses (150–200 kPa) much lower than uniaxial tests (750–2500 kPa), consistent with the low peel tension (∼60 mN/mm). A novel multiscale computational model, including both prefailure and failure mechanics of the aorta, was developed. The microstructural part of the model included contributions from a collagen-reinforced elastin sheet and interlamellar connections representing fibrillin and smooth muscle. Components were represented as nonlinear fibers that failed at a critical stretch. Multiscale simulations of the different experiments were performed, and the model, appropriately specified, agreed well with all experimental data, representing a uniquely complete structure-based description of aorta mechanics. In addition, our experiments and model demonstrate the very low strength of the aorta in radial shear, suggesting an important possible mechanism for aortic dissection.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleFailure of the Porcine Ascending Aorta: Multidirectional Experiments and a Unifying Microstructural Model
    typeJournal Paper
    journal volume139
    journal issue3
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.4035264
    journal fristpage31005
    journal lastpage031005-14
    treeJournal of Biomechanical Engineering:;2017:;volume( 139 ):;issue: 003
    contenttypeFulltext
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    DSpace software copyright © 2002-2015  DuraSpace
    نرم افزار کتابخانه دیجیتال "دی اسپیس" فارسی شده توسط یابش برای کتابخانه های ایرانی | تماس با یابش
    yabeshDSpacePersian