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    Implantable Sensors for Regenerative Medicine

    Source: Journal of Biomechanical Engineering:;2017:;volume( 139 ):;issue: 002::page 21009
    Author:
    Klosterhoff, Brett S.
    ,
    Tsang, Melissa
    ,
    She, Didi
    ,
    Ong, Keat Ghee
    ,
    Allen, Mark G.
    ,
    Willett, Nick J.
    ,
    Guldberg, Robert E.
    DOI: 10.1115/1.4035436
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: The translation of many tissue engineering/regenerative medicine (TE/RM) therapies that demonstrate promise in vitro are delayed or abandoned due to reduced and inconsistent efficacy when implemented in more complex and clinically relevant preclinical in vivo models. Determining mechanistic reasons for impaired treatment efficacy is challenging after a regenerative therapy is implanted due to technical limitations in longitudinally measuring the progression of key environmental cues in vivo. The ability to acquire real-time measurements of environmental parameters of interest including strain, pressure, pH, temperature, oxygen tension, and specific biomarkers within the regenerative niche in situ would significantly enhance the information available to tissue engineers to monitor and evaluate mechanisms of functional healing or lack thereof. Continued advancements in material and fabrication technologies utilized by microelectromechanical systems (MEMSs) and the unique physical characteristics of passive magnetoelastic sensor platforms have created an opportunity to implant small, flexible, low-power sensors into preclinical in vivo models, and quantitatively measure environmental cues throughout healing. In this perspective article, we discuss the need for longitudinal measurements in TE/RM research, technical progress in MEMS and magnetoelastic approaches to implantable sensors, the potential application of implantable sensors to benefit preclinical TE/RM research, and the future directions of collaborative efforts at the intersection of these two important fields.
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      Implantable Sensors for Regenerative Medicine

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    http://yetl.yabesh.ir/yetl1/handle/yetl/4235330
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    contributor authorKlosterhoff, Brett S.
    contributor authorTsang, Melissa
    contributor authorShe, Didi
    contributor authorOng, Keat Ghee
    contributor authorAllen, Mark G.
    contributor authorWillett, Nick J.
    contributor authorGuldberg, Robert E.
    date accessioned2017-11-25T07:18:41Z
    date available2017-11-25T07:18:41Z
    date copyright2017/19/1
    date issued2017
    identifier issn0148-0731
    identifier otherbio_139_02_021009.pdf
    identifier urihttp://138.201.223.254:8080/yetl1/handle/yetl/4235330
    description abstractThe translation of many tissue engineering/regenerative medicine (TE/RM) therapies that demonstrate promise in vitro are delayed or abandoned due to reduced and inconsistent efficacy when implemented in more complex and clinically relevant preclinical in vivo models. Determining mechanistic reasons for impaired treatment efficacy is challenging after a regenerative therapy is implanted due to technical limitations in longitudinally measuring the progression of key environmental cues in vivo. The ability to acquire real-time measurements of environmental parameters of interest including strain, pressure, pH, temperature, oxygen tension, and specific biomarkers within the regenerative niche in situ would significantly enhance the information available to tissue engineers to monitor and evaluate mechanisms of functional healing or lack thereof. Continued advancements in material and fabrication technologies utilized by microelectromechanical systems (MEMSs) and the unique physical characteristics of passive magnetoelastic sensor platforms have created an opportunity to implant small, flexible, low-power sensors into preclinical in vivo models, and quantitatively measure environmental cues throughout healing. In this perspective article, we discuss the need for longitudinal measurements in TE/RM research, technical progress in MEMS and magnetoelastic approaches to implantable sensors, the potential application of implantable sensors to benefit preclinical TE/RM research, and the future directions of collaborative efforts at the intersection of these two important fields.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleImplantable Sensors for Regenerative Medicine
    typeJournal Paper
    journal volume139
    journal issue2
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.4035436
    journal fristpage21009
    journal lastpage021009-11
    treeJournal of Biomechanical Engineering:;2017:;volume( 139 ):;issue: 002
    contenttypeFulltext
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    DSpace software copyright © 2002-2015  DuraSpace
    نرم افزار کتابخانه دیجیتال "دی اسپیس" فارسی شده توسط یابش برای کتابخانه های ایرانی | تماس با یابش
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