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    Magnetic Shape Memory Micropump for Submicroliter Intracranial Drug Delivery in Rats

    Source: Journal of Medical Devices:;2016:;volume( 010 ):;issue: 004::page 41009
    Author:
    Barker, Samuel
    ,
    Rhoads, Eric
    ,
    Lindquist, Paul
    ,
    Vreugdenhil, Martin
    ,
    Müllner, Peter
    DOI: 10.1115/1.4034576
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Point-of-care diagnostic devices, micrototal analysis (μTAS) systems, lab-on-a-chip development, and biomedical research rely heavily upon microfluidic management and innovative micropump design. Here, we describe the design and prototype deployment of a magnetic shape memory (MSM) micropump capable of submicroliter per minute flow rates. The pump contains no valves or moving parts in the fluid channel and is capable of bidirectional fluid transport. This pump was employed as the mechanism to deliver small intracranial dosages of ketamine and tetrodotoxin (TTX) at 0.33 μl/min during in vivo electrophysiological recordings in anesthetized rats, performing to required specifications.
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      Magnetic Shape Memory Micropump for Submicroliter Intracranial Drug Delivery in Rats

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    contributor authorBarker, Samuel
    contributor authorRhoads, Eric
    contributor authorLindquist, Paul
    contributor authorVreugdenhil, Martin
    contributor authorMüllner, Peter
    date accessioned2017-11-25T07:18:23Z
    date available2017-11-25T07:18:23Z
    date copyright2016/09/12
    date issued2016
    identifier issn1932-6181
    identifier othermed_010_04_041009.pdf
    identifier urihttp://138.201.223.254:8080/yetl1/handle/yetl/4235177
    description abstractPoint-of-care diagnostic devices, micrototal analysis (μTAS) systems, lab-on-a-chip development, and biomedical research rely heavily upon microfluidic management and innovative micropump design. Here, we describe the design and prototype deployment of a magnetic shape memory (MSM) micropump capable of submicroliter per minute flow rates. The pump contains no valves or moving parts in the fluid channel and is capable of bidirectional fluid transport. This pump was employed as the mechanism to deliver small intracranial dosages of ketamine and tetrodotoxin (TTX) at 0.33 μl/min during in vivo electrophysiological recordings in anesthetized rats, performing to required specifications.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleMagnetic Shape Memory Micropump for Submicroliter Intracranial Drug Delivery in Rats
    typeJournal Paper
    journal volume10
    journal issue4
    journal titleJournal of Medical Devices
    identifier doi10.1115/1.4034576
    journal fristpage41009
    journal lastpage041009-6
    treeJournal of Medical Devices:;2016:;volume( 010 ):;issue: 004
    contenttypeFulltext
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    DSpace software copyright © 2002-2015  DuraSpace
    نرم افزار کتابخانه دیجیتال "دی اسپیس" فارسی شده توسط یابش برای کتابخانه های ایرانی | تماس با یابش
    yabeshDSpacePersian