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contributor authorAmini Khoiy, Keyvan
contributor authorBiswas, Dipankar
contributor authorDecker, Thomas N.
contributor authorAsgarian, Kourosh T.
contributor authorLoth, Francis
contributor authorAmini, Rouzbeh
date accessioned2017-11-25T07:17:53Z
date available2017-11-25T07:17:53Z
date copyright2016/10/21
date issued2016
identifier issn0148-0731
identifier otherbio_138_11_111006.pdf
identifier urihttp://138.201.223.254:8080/yetl1/handle/yetl/4234820
description abstractQuantification of the tricuspid valve (TV) leaflets mechanical strain is important in order to understand valve pathophysiology and to develop effective treatment strategies. Many of the traditional methods used to dynamically open and close the cardiac valves in vitro via flow simulators require valve dissection. Recent studies, however, have shown that restriction of the atrioventricular valve annuli could significantly change their in vivo deformation. For the first time, the porcine valve leaflets deformation was measured in a passive ex vivo beating heart without isolating and remounting the valve annuli. In particular, the right ventricular apexes of porcine hearts (n = 8) were connected to a pulse-duplicator pump that maintained a pulsatile flow from and to a reservoir connected to the right atrium and the pulmonary arteries. This pump provided a right ventricular pressure (RVP) waveform that closely matched physiological values, leading to opening and closure of the tricuspid and pulmonary valves (PVs). At the midsection of the valve leaflets, the peak areal strain was 9.8 ± 2.0% (mean±standard error). The peak strain was 5.6 ± 1.1% and 4.3 ± 1.0% in the circumferential and radial directions, respectively. Although the right ventricle was beating passively, the leaflet peak areal strains closely matched the values measured in other atrioventricular valves (i.e., the mitral valve (MV)) in vivo. This technique can be used to measure leaflet strains with and without the presence of valve lesions to help develop/evaluate treatment strategies to restore normal valve deformation.
publisherThe American Society of Mechanical Engineers (ASME)
titleSurface Strains of Porcine Tricuspid Valve Septal Leaflets Measured in Ex Vivo Beating Hearts
typeJournal Paper
journal volume138
journal issue11
journal titleJournal of Biomechanical Engineering
identifier doi10.1115/1.4034621
journal fristpage111006
journal lastpage111006-9
treeJournal of Biomechanical Engineering:;2016:;volume( 138 ):;issue: 011
contenttypeFulltext


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