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    Size Dependent Nanoparticle Uptake by Endothelial Cells in a Capillary Flow System

    Source: Journal of Nanotechnology in Engineering and Medicine:;2015:;volume( 006 ):;issue: 001::page 11007
    Author:
    Jurney, Patrick
    ,
    Agarwal, Rachit
    ,
    Roy, Krishnendu
    ,
    Sreenivasan, S. V.
    ,
    Shi, Li
    DOI: 10.1115/1.4031856
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: An in vitro cell culture system is developed for studying the uptake characteristics of nanoparticles (NPs) by endothelial cells under shear stress. Results show that the smaller polystyrene nanospheres are uptaken more than larger nanospheres for sizes ranging from 100 nm to 500 nm for 12, 24, and 48 hrs delivery times. While the result is similar to that found in static cultures, the observed trend is different from NP delivery behaviors to a simple glass surface in a flow, where no clear size dependence was observed because of repulsive electrostatic force on marginating NPs. The trend is also opposite to the behavior found in another study of the adhesion of labeled particles onto endothelial cells in whole blood flow. The comparison shows that the reduced zeta potential of NPs in a serumcontaining cell medium and particle removal by cells results in reduced repulsive electrostatic force on marginating NPs. Consequently, the uptake behaviors are dominated by Brownian diffusion and cell membrane deformation process, which favor the uptake of NPs with reduced sizes.
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      Size Dependent Nanoparticle Uptake by Endothelial Cells in a Capillary Flow System

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    contributor authorJurney, Patrick
    contributor authorAgarwal, Rachit
    contributor authorRoy, Krishnendu
    contributor authorSreenivasan, S. V.
    contributor authorShi, Li
    date accessioned2017-05-09T01:22:11Z
    date available2017-05-09T01:22:11Z
    date issued2015
    identifier issn1949-2944
    identifier othernano_006_01_011007.pdf
    identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/159255
    description abstractAn in vitro cell culture system is developed for studying the uptake characteristics of nanoparticles (NPs) by endothelial cells under shear stress. Results show that the smaller polystyrene nanospheres are uptaken more than larger nanospheres for sizes ranging from 100 nm to 500 nm for 12, 24, and 48 hrs delivery times. While the result is similar to that found in static cultures, the observed trend is different from NP delivery behaviors to a simple glass surface in a flow, where no clear size dependence was observed because of repulsive electrostatic force on marginating NPs. The trend is also opposite to the behavior found in another study of the adhesion of labeled particles onto endothelial cells in whole blood flow. The comparison shows that the reduced zeta potential of NPs in a serumcontaining cell medium and particle removal by cells results in reduced repulsive electrostatic force on marginating NPs. Consequently, the uptake behaviors are dominated by Brownian diffusion and cell membrane deformation process, which favor the uptake of NPs with reduced sizes.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleSize Dependent Nanoparticle Uptake by Endothelial Cells in a Capillary Flow System
    typeJournal Paper
    journal volume6
    journal issue1
    journal titleJournal of Nanotechnology in Engineering and Medicine
    identifier doi10.1115/1.4031856
    journal fristpage11007
    journal lastpage11007
    identifier eissn1949-2952
    treeJournal of Nanotechnology in Engineering and Medicine:;2015:;volume( 006 ):;issue: 001
    contenttypeFulltext
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    DSpace software copyright © 2002-2015  DuraSpace
    نرم افزار کتابخانه دیجیتال "دی اسپیس" فارسی شده توسط یابش برای کتابخانه های ایرانی | تماس با یابش
    yabeshDSpacePersian