Effect of Hydration on Healthy Intervertebral Disk Mechanical StiffnessSource: Journal of Biomechanical Engineering:;2015:;volume( 137 ):;issue: 010::page 101007DOI: 10.1115/1.4031416Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: The intervertebral disk has an excellent swelling capacity to absorb water, which is thought to be largely due to the high proteoglycan composition. Injury, aging, degeneration, and diurnal loading are all noted by a significant decrease in water content and tissue hydration. The objective of this study was to evaluate the effect of hydration, through osmotic loading, on tissue swelling and compressive stiffness of healthy intervertebral disks. The wet weight of nucleus pulposus (NP) and annulus fibrosus (AF) explants following swelling was 50% or greater, demonstrating significant ability to absorb water under all osmotic loading conditions (0.015 M–3.0 M phosphate buffered saline (PBS)). Estimated NP residual strains, calculated from the swelling ratio, were approximately 1.5 أ— greater than AF residual strains. Compressive stiffness increased with hyperosmotic loading, which is thought to be due to material compaction from osmoticloading and the nonlinear mechanical behavior. Importantly, this study demonstrated that residual strains and material properties are greatly dependent on osmotic loading. The findings of this study support the notion that swelling properties from osmotic loading will be important for accurately describing the effect of degeneration and injury on disk mechanics. Furthermore, the tissue swelling will be an important consideration for developing biological repair strategies aimed at restoring mechanical behavior toward a healthy disk.
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contributor author | Bezci, Semih E. | |
contributor author | Nandy, Aditya | |
contributor author | O'Connell, Grace D. | |
date accessioned | 2017-05-09T01:15:25Z | |
date available | 2017-05-09T01:15:25Z | |
date issued | 2015 | |
identifier issn | 0148-0731 | |
identifier other | bio_137_10_101007.pdf | |
identifier uri | http://yetl.yabesh.ir/yetl/handle/yetl/157191 | |
description abstract | The intervertebral disk has an excellent swelling capacity to absorb water, which is thought to be largely due to the high proteoglycan composition. Injury, aging, degeneration, and diurnal loading are all noted by a significant decrease in water content and tissue hydration. The objective of this study was to evaluate the effect of hydration, through osmotic loading, on tissue swelling and compressive stiffness of healthy intervertebral disks. The wet weight of nucleus pulposus (NP) and annulus fibrosus (AF) explants following swelling was 50% or greater, demonstrating significant ability to absorb water under all osmotic loading conditions (0.015 M–3.0 M phosphate buffered saline (PBS)). Estimated NP residual strains, calculated from the swelling ratio, were approximately 1.5 أ— greater than AF residual strains. Compressive stiffness increased with hyperosmotic loading, which is thought to be due to material compaction from osmoticloading and the nonlinear mechanical behavior. Importantly, this study demonstrated that residual strains and material properties are greatly dependent on osmotic loading. The findings of this study support the notion that swelling properties from osmotic loading will be important for accurately describing the effect of degeneration and injury on disk mechanics. Furthermore, the tissue swelling will be an important consideration for developing biological repair strategies aimed at restoring mechanical behavior toward a healthy disk. | |
publisher | The American Society of Mechanical Engineers (ASME) | |
title | Effect of Hydration on Healthy Intervertebral Disk Mechanical Stiffness | |
type | Journal Paper | |
journal volume | 137 | |
journal issue | 10 | |
journal title | Journal of Biomechanical Engineering | |
identifier doi | 10.1115/1.4031416 | |
journal fristpage | 101007 | |
journal lastpage | 101007 | |
identifier eissn | 1528-8951 | |
tree | Journal of Biomechanical Engineering:;2015:;volume( 137 ):;issue: 010 | |
contenttype | Fulltext |