Bioengineered Stromal Cell Derived Factor 1خ± Analogue Delivered as an Angiogenic Therapy Significantly Restores Viscoelastic Material Properties of Infarcted Cardiac MuscleSource: Journal of Biomechanical Engineering:;2014:;volume( 136 ):;issue: 008::page 84501Author:Trubelja, Alen
,
MacArthur, John W.
,
Sarver, Joseph J.
,
Cohen, Jeffrey E.
,
Hung, George
,
Shudo, Yasuhiro
,
Fairman, Alexander S.
,
Patel, Jay
,
Edwards, Bryan B.
,
Damrauer, Scott M.
,
Hiesinger, William
,
Atluri, Pavan
,
Joseph Woo, Y.
DOI: 10.1115/1.4027731Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Ischemic heart disease is a major health problem worldwide, and current therapies fail to address microrevascularization. Previously, our group demonstrated that the sustained release of novel engineered stromal cellderived factor 1خ± analogue (ESA) limits infarct spreading, collagen deposition, improves cardiac function by promoting angiogenesis in the region surrounding the infarct, and restores the tensile properties of infarcted myocardium. In this study, using a wellestablished rat model of ischemic cardiomyopathy, we describe a novel and innovative method for analyzing the viscoelastic properties of infarcted myocardium. Our results demonstrate that, compared with a saline control group, animals treated with ESA have significantly improved myocardial relaxation rates, while reducing the transition strain, leading to restoration of left ventricular mechanics.
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| contributor author | Trubelja, Alen | |
| contributor author | MacArthur, John W. | |
| contributor author | Sarver, Joseph J. | |
| contributor author | Cohen, Jeffrey E. | |
| contributor author | Hung, George | |
| contributor author | Shudo, Yasuhiro | |
| contributor author | Fairman, Alexander S. | |
| contributor author | Patel, Jay | |
| contributor author | Edwards, Bryan B. | |
| contributor author | Damrauer, Scott M. | |
| contributor author | Hiesinger, William | |
| contributor author | Atluri, Pavan | |
| contributor author | Joseph Woo, Y. | |
| date accessioned | 2017-05-09T01:05:35Z | |
| date available | 2017-05-09T01:05:35Z | |
| date issued | 2014 | |
| identifier issn | 0148-0731 | |
| identifier other | bio_136_08_084501.pdf | |
| identifier uri | http://yetl.yabesh.ir/yetl/handle/yetl/154054 | |
| description abstract | Ischemic heart disease is a major health problem worldwide, and current therapies fail to address microrevascularization. Previously, our group demonstrated that the sustained release of novel engineered stromal cellderived factor 1خ± analogue (ESA) limits infarct spreading, collagen deposition, improves cardiac function by promoting angiogenesis in the region surrounding the infarct, and restores the tensile properties of infarcted myocardium. In this study, using a wellestablished rat model of ischemic cardiomyopathy, we describe a novel and innovative method for analyzing the viscoelastic properties of infarcted myocardium. Our results demonstrate that, compared with a saline control group, animals treated with ESA have significantly improved myocardial relaxation rates, while reducing the transition strain, leading to restoration of left ventricular mechanics. | |
| publisher | The American Society of Mechanical Engineers (ASME) | |
| title | Bioengineered Stromal Cell Derived Factor 1خ± Analogue Delivered as an Angiogenic Therapy Significantly Restores Viscoelastic Material Properties of Infarcted Cardiac Muscle | |
| type | Journal Paper | |
| journal volume | 136 | |
| journal issue | 8 | |
| journal title | Journal of Biomechanical Engineering | |
| identifier doi | 10.1115/1.4027731 | |
| journal fristpage | 84501 | |
| journal lastpage | 84501 | |
| identifier eissn | 1528-8951 | |
| tree | Journal of Biomechanical Engineering:;2014:;volume( 136 ):;issue: 008 | |
| contenttype | Fulltext |