Evaluation of Meniscal Mechanics and Proteoglycan Content in a Modified Anterior Cruciate Ligament Transection ModelSource: Journal of Biomechanical Engineering:;2014:;volume( 136 ):;issue: 007::page 71001Author:Fischenich, Kristine M.
,
Coatney, Garrett A.
,
Haverkamp, John H.
,
Button, Keith D.
,
DeCamp, Charlie
,
Haut, Roger C.
,
Haut Donahue, Tammy L.
DOI: 10.1115/1.4027468Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Posttraumatic osteoarthritis (PTOA) develops as a result of traumatic loading that causes tears of the soft tissues in the knee. A modified transection model, where the anterior cruciate ligament (ACL) and both menisci were transected, was used on skeletally mature Flemish Giant rabbits. Gross morphological assessments, elastic moduli, and glycosaminoglycan (GAG) coverage of the menisci were determined to quantify the amount of tissue damage 12 weeks post injury. This study is one of the first to monitor meniscal changes after inducing combined meniscal and ACL transections. A decrease in elastic moduli as well as a decrease in GAG coverage was seen.
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| contributor author | Fischenich, Kristine M. | |
| contributor author | Coatney, Garrett A. | |
| contributor author | Haverkamp, John H. | |
| contributor author | Button, Keith D. | |
| contributor author | DeCamp, Charlie | |
| contributor author | Haut, Roger C. | |
| contributor author | Haut Donahue, Tammy L. | |
| date accessioned | 2017-05-09T01:05:29Z | |
| date available | 2017-05-09T01:05:29Z | |
| date issued | 2014 | |
| identifier issn | 0148-0731 | |
| identifier other | bio_136_07_071001.pdf | |
| identifier uri | http://yetl.yabesh.ir/yetl/handle/yetl/154025 | |
| description abstract | Posttraumatic osteoarthritis (PTOA) develops as a result of traumatic loading that causes tears of the soft tissues in the knee. A modified transection model, where the anterior cruciate ligament (ACL) and both menisci were transected, was used on skeletally mature Flemish Giant rabbits. Gross morphological assessments, elastic moduli, and glycosaminoglycan (GAG) coverage of the menisci were determined to quantify the amount of tissue damage 12 weeks post injury. This study is one of the first to monitor meniscal changes after inducing combined meniscal and ACL transections. A decrease in elastic moduli as well as a decrease in GAG coverage was seen. | |
| publisher | The American Society of Mechanical Engineers (ASME) | |
| title | Evaluation of Meniscal Mechanics and Proteoglycan Content in a Modified Anterior Cruciate Ligament Transection Model | |
| type | Journal Paper | |
| journal volume | 136 | |
| journal issue | 7 | |
| journal title | Journal of Biomechanical Engineering | |
| identifier doi | 10.1115/1.4027468 | |
| journal fristpage | 71001 | |
| journal lastpage | 71001 | |
| identifier eissn | 1528-8951 | |
| tree | Journal of Biomechanical Engineering:;2014:;volume( 136 ):;issue: 007 | |
| contenttype | Fulltext |