contributor author | Pfeiffer, Emily R. | |
contributor author | Tangney, Jared R. | |
contributor author | Omens, Jeffrey H. | |
contributor author | McCulloch, Andrew D. | |
date accessioned | 2017-05-09T01:05:14Z | |
date available | 2017-05-09T01:05:14Z | |
date issued | 2014 | |
identifier issn | 0148-0731 | |
identifier other | bio_136_02_021007.pdf | |
identifier uri | http://yetl.yabesh.ir/yetl/handle/yetl/153944 | |
description abstract | Cardiac mechanical contraction is triggered by electrical activation via an intracellular calciumdependent process known as excitation–contraction coupling. Dysregulation of cardiac myocyte intracellular calcium handling is a common feature of heart failure. At the organ scale, electrical dyssynchrony leads to mechanical alterations and exacerbates pump dysfunction in heart failure. A reverse coupling between cardiac mechanics and electrophysiology is also well established. It is commonly referred as cardiac mechanoelectric feedback and thought to be an important contributor to the increased risk of arrhythmia during pathological conditions that alter regional cardiac wall mechanics, including heart failure. At the cellular scale, most investigations of myocyte mechanoelectric feedback have focused on the roles of stretchactivated ion channels, though mechanisms that are independent of ionic currents have also been described. Here we review excitation–contraction coupling and mechanoelectric feedback at the cellular and organ scales, and we identify the need for new multicellular tissuescale model systems and experiments that can help us to obtain a better understanding of how interactions between electrophysiological and mechanical processes at the cell scale affect ventricular electromechanical interactions at the organ scale in the normal and diseased heart. | |
publisher | The American Society of Mechanical Engineers (ASME) | |
title | Biomechanics of Cardiac Electromechanical Coupling and Mechanoelectric Feedback | |
type | Journal Paper | |
journal volume | 136 | |
journal issue | 2 | |
journal title | Journal of Biomechanical Engineering | |
identifier doi | 10.1115/1.4026221 | |
journal fristpage | 21007 | |
journal lastpage | 21007 | |
identifier eissn | 1528-8951 | |
tree | Journal of Biomechanical Engineering:;2014:;volume( 136 ):;issue: 002 | |
contenttype | Fulltext | |