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    Transport of Dynamic Biochemical Signals in Steady Flow in a Shallow Y Shaped Microfluidic Channel: Effect of Transverse Diffusion and Longitudinal Dispersion

    Source: Journal of Biomechanical Engineering:;2013:;volume( 135 ):;issue: 012::page 121011
    Author:
    Li, Yong
    ,
    Li, Yizeng
    ,
    Cao, Tun
    ,
    Qin, Kai
    DOI: 10.1115/1.4025774
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Dynamic biochemical signal control is important in in vitro cell studies. This work analyzes the transportation of dynamic biochemical signals in steady and mixing flow in a shallow, Yshaped microfluidic channel. The characteristics of transportation of different signals are investigated, and the combined effect of transverse diffusion and longitudinal dispersion is studied. A method is presented to control the widths of two steady flows in the mixing channel from two inlets. The transfer function and the cutoff frequency of the mixing channel as a transmission system are presented by analytically solving the governing equations for the timedependent Taylor–Aris dispersion and molecular diffusion. The amplitude and phase spectra show that the mixing Yshaped microfluidic channel acts as a lowpass filter due to the longitudinal dispersion. With transverse molecular diffusion, the magnitudes of the output dynamic signal are reduced compared to those without transverse molecular diffusion. The inverse problem of signal transportation for signal control is also solved and analyzed.
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      Transport of Dynamic Biochemical Signals in Steady Flow in a Shallow Y Shaped Microfluidic Channel: Effect of Transverse Diffusion and Longitudinal Dispersion

    URI
    http://yetl.yabesh.ir/yetl1/handle/yetl/151142
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    • Journal of Biomechanical Engineering

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    contributor authorLi, Yong
    contributor authorLi, Yizeng
    contributor authorCao, Tun
    contributor authorQin, Kai
    date accessioned2017-05-09T00:56:57Z
    date available2017-05-09T00:56:57Z
    date issued2013
    identifier issn0148-0731
    identifier otherbio_135_12_121011.pdf
    identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/151142
    description abstractDynamic biochemical signal control is important in in vitro cell studies. This work analyzes the transportation of dynamic biochemical signals in steady and mixing flow in a shallow, Yshaped microfluidic channel. The characteristics of transportation of different signals are investigated, and the combined effect of transverse diffusion and longitudinal dispersion is studied. A method is presented to control the widths of two steady flows in the mixing channel from two inlets. The transfer function and the cutoff frequency of the mixing channel as a transmission system are presented by analytically solving the governing equations for the timedependent Taylor–Aris dispersion and molecular diffusion. The amplitude and phase spectra show that the mixing Yshaped microfluidic channel acts as a lowpass filter due to the longitudinal dispersion. With transverse molecular diffusion, the magnitudes of the output dynamic signal are reduced compared to those without transverse molecular diffusion. The inverse problem of signal transportation for signal control is also solved and analyzed.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleTransport of Dynamic Biochemical Signals in Steady Flow in a Shallow Y Shaped Microfluidic Channel: Effect of Transverse Diffusion and Longitudinal Dispersion
    typeJournal Paper
    journal volume135
    journal issue12
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.4025774
    journal fristpage121011
    journal lastpage121011
    identifier eissn1528-8951
    treeJournal of Biomechanical Engineering:;2013:;volume( 135 ):;issue: 012
    contenttypeFulltext
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