contributor author | Pei, Xuan | |
contributor author | Wu, Baijian | |
contributor author | Li, Zhi | |
date accessioned | 2017-05-09T00:56:48Z | |
date available | 2017-05-09T00:56:48Z | |
date issued | 2013 | |
identifier issn | 0148-0731 | |
identifier other | bio_135_10_101003.pdf | |
identifier uri | http://yetl.yabesh.ir/yetl/handle/yetl/151097 | |
description abstract | Rupture of atheromatous plaque is the major cause of stroke or heart attack. Considering that the cardiovascular system is a classic fatigue environment, plaque rupture was treated as a chronic fatigue crack growth process in this study. Fracture mechanics theory was introduced to describe the stress status at the crack tip and Paris' law was used to calculate the crack growth rate. The effect of anatomical variation of an idealized plaque crosssection model was investigated. The crack initiation was considered to be either at the maximum circumferential stress location or at any other possible locations around the lumen. Although the crack automatically initialized at the maximum circumferential stress location usually propagated faster than others, it was not necessarily the most critical location where the fatigue life reached its minimum. We found that the fatigue life was minimum for cracks initialized in the following three regions: the midcap zone, the shoulder zone, and the backside zone. The anatomical variation has a significant influence on the fatigue life. Either a decrease in cap thickness or an increase in lipid pool size resulted in a significant decrease in fatigue life. Comparing to the previously used stress analysis, this fatigue model provides some possible explanations of plaque rupture at a low stress level in a pulsatile cardiovascular environment, and the method proposed here may be useful for further investigation of the mechanism of plaque rupture based on in vivo patient data. | |
publisher | The American Society of Mechanical Engineers (ASME) | |
title | Fatigue Crack Propagation Analysis of Plaque Rupture | |
type | Journal Paper | |
journal volume | 135 | |
journal issue | 10 | |
journal title | Journal of Biomechanical Engineering | |
identifier doi | 10.1115/1.4025106 | |
journal fristpage | 101003 | |
journal lastpage | 101003 | |
identifier eissn | 1528-8951 | |
tree | Journal of Biomechanical Engineering:;2013:;volume( 135 ):;issue: 010 | |
contenttype | Fulltext | |