A New Catheter for Tumor-Targeting With Radioactive Microspheres in Representative Hepatic Artery Systems—Part II: Solid Tumor-Targeting in a Patient-Inspired Hepatic Artery SystemSource: Journal of Biomechanical Engineering:;2012:;volume( 134 ):;issue: 005::page 51005DOI: 10.1115/1.4006685Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: In this second part, the methodology for optimal tumor-targeting is further explored, employing a patient-inspired hepatic artery system which differs significantly from the idealized configuration discussed in Part I. Furthermore, the fluid dynamics of a microsphere supply apparatus is also analyzed. The best radial catheter positions and particle-release intervals for tumor targeting were determined for both the idealized and patient-inspired configurations. This was accomplished by numerically analyzing generated particle release maps (PRMs) for ten equally spaced intervals throughout the pulse. As in Part I, the effects of introducing a catheter were also investigated. In addition to the determination of micro-catheter positioning and, hence, optimal microsphere release, a microsphere-supply apparatus (MSA) was analyzed, which transports the particles to the catheter-nozzle, considering different axial particle injection functions, i.e., step, ramp, and S-curve. A refined targeting methodology was developed which demonstrates how the optimal injection region and interval can be determined with the presence of a catheter for any geometric configuration. Additionally, the less abrupt injection functions (i.e., ramp and S-curve) were shown to provide a more compact particle stream, making them better choices for targeting. The results of this study aid in designing the smart micro-catheter (SMC) in conjunction with the MSA, bringing this innovative treatment procedure one step closer to implementation in clinical practice.
keyword(s): Particulate matter , Catheters , Liver , Tumors , Functions AND Vessels ,
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contributor author | E. M. Childress | |
contributor author | C. Kleinstreuer | |
contributor author | A. S. Kennedy | |
date accessioned | 2017-05-09T00:48:31Z | |
date available | 2017-05-09T00:48:31Z | |
date copyright | May, 2012 | |
date issued | 2012 | |
identifier issn | 0148-0731 | |
identifier other | JBENDY-28993#051005_1.pdf | |
identifier uri | http://yetl.yabesh.ir/yetl/handle/yetl/148254 | |
description abstract | In this second part, the methodology for optimal tumor-targeting is further explored, employing a patient-inspired hepatic artery system which differs significantly from the idealized configuration discussed in Part I. Furthermore, the fluid dynamics of a microsphere supply apparatus is also analyzed. The best radial catheter positions and particle-release intervals for tumor targeting were determined for both the idealized and patient-inspired configurations. This was accomplished by numerically analyzing generated particle release maps (PRMs) for ten equally spaced intervals throughout the pulse. As in Part I, the effects of introducing a catheter were also investigated. In addition to the determination of micro-catheter positioning and, hence, optimal microsphere release, a microsphere-supply apparatus (MSA) was analyzed, which transports the particles to the catheter-nozzle, considering different axial particle injection functions, i.e., step, ramp, and S-curve. A refined targeting methodology was developed which demonstrates how the optimal injection region and interval can be determined with the presence of a catheter for any geometric configuration. Additionally, the less abrupt injection functions (i.e., ramp and S-curve) were shown to provide a more compact particle stream, making them better choices for targeting. The results of this study aid in designing the smart micro-catheter (SMC) in conjunction with the MSA, bringing this innovative treatment procedure one step closer to implementation in clinical practice. | |
publisher | The American Society of Mechanical Engineers (ASME) | |
title | A New Catheter for Tumor-Targeting With Radioactive Microspheres in Representative Hepatic Artery Systems—Part II: Solid Tumor-Targeting in a Patient-Inspired Hepatic Artery System | |
type | Journal Paper | |
journal volume | 134 | |
journal issue | 5 | |
journal title | Journal of Biomechanical Engineering | |
identifier doi | 10.1115/1.4006685 | |
journal fristpage | 51005 | |
identifier eissn | 1528-8951 | |
keywords | Particulate matter | |
keywords | Catheters | |
keywords | Liver | |
keywords | Tumors | |
keywords | Functions AND Vessels | |
tree | Journal of Biomechanical Engineering:;2012:;volume( 134 ):;issue: 005 | |
contenttype | Fulltext |