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    The Effect of Shape Factor on the Magnetic Targeting in the Permeable Microvessel With Two-Phase Casson Fluid Model

    Source: Journal of Nanotechnology in Engineering and Medicine:;2011:;volume( 002 ):;issue: 004::page 41003
    Author:
    Sachin Shaw
    ,
    P. V. S. N. Murthy
    DOI: 10.1115/1.4005675
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: The present investigation deals with magnetic drug targeting in a microvessel of radius 5 μm using two-phase fluid model. The microvessel is divided into the endothelial glycocalyx layer wherein the blood obeys Newtonian character and a core region wherein the blood obeys the non-Newtonian Casson fluid character. The carrier particles, bound with nanoparticles and drug molecules, are injected into the vascular system upstream from the malignant tissue and are captured at the tumor site using a local applied magnetic field near the tumor position. Brinkman model is used to characterize the permeable nature of the inner wall of the microvessel. The expressions for the fluidic force for the carrier particle traversing in the two-phase fluid in the microvessel and the magnetic force due to the external magnetic field are obtained. Several factors that influence the magnetic targeting of the carrier particles in the microvasculature, such as the size and shape of the carrier particle, the volume fraction of embedded magnetic nanoparticles, and the distance of separation of the magnet from the axis of the microvessel, are considered in the present problem. The system of coupled equations is solved to obtain the trajectories of the carrier particle in the noninvasive case.
    keyword(s): Fluids , Particulate matter , Shapes , Magnets , Magnetic fields , Tumors , Blood , Force , Nanoparticles AND Drugs ,
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      The Effect of Shape Factor on the Magnetic Targeting in the Permeable Microvessel With Two-Phase Casson Fluid Model

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    http://yetl.yabesh.ir/yetl1/handle/yetl/147285
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    contributor authorSachin Shaw
    contributor authorP. V. S. N. Murthy
    date accessioned2017-05-09T00:46:15Z
    date available2017-05-09T00:46:15Z
    date copyrightNovember, 2011
    date issued2011
    identifier issn1949-2944
    identifier otherJNEMAA-28072#041003_1.pdf
    identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/147285
    description abstractThe present investigation deals with magnetic drug targeting in a microvessel of radius 5 μm using two-phase fluid model. The microvessel is divided into the endothelial glycocalyx layer wherein the blood obeys Newtonian character and a core region wherein the blood obeys the non-Newtonian Casson fluid character. The carrier particles, bound with nanoparticles and drug molecules, are injected into the vascular system upstream from the malignant tissue and are captured at the tumor site using a local applied magnetic field near the tumor position. Brinkman model is used to characterize the permeable nature of the inner wall of the microvessel. The expressions for the fluidic force for the carrier particle traversing in the two-phase fluid in the microvessel and the magnetic force due to the external magnetic field are obtained. Several factors that influence the magnetic targeting of the carrier particles in the microvasculature, such as the size and shape of the carrier particle, the volume fraction of embedded magnetic nanoparticles, and the distance of separation of the magnet from the axis of the microvessel, are considered in the present problem. The system of coupled equations is solved to obtain the trajectories of the carrier particle in the noninvasive case.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleThe Effect of Shape Factor on the Magnetic Targeting in the Permeable Microvessel With Two-Phase Casson Fluid Model
    typeJournal Paper
    journal volume2
    journal issue4
    journal titleJournal of Nanotechnology in Engineering and Medicine
    identifier doi10.1115/1.4005675
    journal fristpage41003
    identifier eissn1949-2952
    keywordsFluids
    keywordsParticulate matter
    keywordsShapes
    keywordsMagnets
    keywordsMagnetic fields
    keywordsTumors
    keywordsBlood
    keywordsForce
    keywordsNanoparticles AND Drugs
    treeJournal of Nanotechnology in Engineering and Medicine:;2011:;volume( 002 ):;issue: 004
    contenttypeFulltext
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