PneumoniaCheck: A Device for Sampling Lower Airway Aerosols

Abstract

The pathogens causing pneumonia are difficult to identify because a high quality specimen from the lower lung is difficult to obtain. A new specimen collection device is designed to collect aerosol specimens selectively from the lower lung generated during deep coughing. The PneumoniaCheck device utilizes a separation reservoir and Venturi valve to segregate contents from the upper and lower airways. The device also includes several specially designed features to exclude oral contaminants from the sample and a filter to collect the aerosolized pathogens. Verification testing of PneumoniaCheck demonstrates effective separation of upper airway gas from the lower airway gas (p<0.0001) and exclusion of both liquid and viscous oral material (p<0.0001) from the collection chamber. The filters can collect 99.9997% of virus and bacteria sized particles from the sampled lower lung aerosols. The selective collection of specimens from the lower airway may aid in the diagnosis of specific pathogens causing pneumonia.