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    Development of a Multifunction Isolator System for the Care of Medium-Sized Laboratory Animals Harboring Infectious Diseases

    Source: Journal of Medical Devices:;2010:;volume( 004 ):;issue: 004::page 41004
    Author:
    Xin Pan
    ,
    Ming Long
    ,
    Hao Liang
    ,
    Xiao Chen
    ,
    Han Li
    ,
    Guang-bo Li
    ,
    Zi-ye Zhao
    DOI: 10.1115/1.4002623
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: The close phylogenetic relationship between humans and nonhuman primates makes nonhuman primates an irreplaceable model for the study of human infectious diseases. In this study, we describe the development of an automatic multifunctional isolation chamber for use with medium-sized laboratory animals carrying an infectious disease. The isolator system, including the transfer chain, disinfection chain, negative air pressure isolation system, animal welfare system, and the automated system, was designed to meet all biological safety standards. To create an internal chamber environment that was completely isolated from the exterior, variable frequency drive blowers were used in the air-intake and air-exhaust system, precisely controlling the filtered airflow and providing an air-barrier protection. To transfer the material between the interior of the isolation chamber and the outside, a double door transfer port was used. A peracetic acid sterilizer and its affiliated pipeline allowed for a complete disinfection of the isolation chamber. All of the isolator system parameters can be automatically controlled by a programmable computerized menu allowing for work with different animals in different sized cages depending on the research project. The multifunctional isolator system should be a useful safety device for working with medium-sized laboratory infectious animals in high-level biosafety laboratories.
    keyword(s): Pressure , Doors , Diseases , Exhaust systems , Screens (Mining) , Valves , Ventilation , Stainless steel , Screws , Air flow , Sterilization AND Safety ,
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      Development of a Multifunction Isolator System for the Care of Medium-Sized Laboratory Animals Harboring Infectious Diseases

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    http://yetl.yabesh.ir/yetl1/handle/yetl/144373
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    • Journal of Medical Devices

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    contributor authorXin Pan
    contributor authorMing Long
    contributor authorHao Liang
    contributor authorXiao Chen
    contributor authorHan Li
    contributor authorGuang-bo Li
    contributor authorZi-ye Zhao
    date accessioned2017-05-09T00:39:57Z
    date available2017-05-09T00:39:57Z
    date copyrightDecember, 2010
    date issued2010
    identifier issn1932-6181
    identifier otherJMDOA4-28014#041004_1.pdf
    identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/144373
    description abstractThe close phylogenetic relationship between humans and nonhuman primates makes nonhuman primates an irreplaceable model for the study of human infectious diseases. In this study, we describe the development of an automatic multifunctional isolation chamber for use with medium-sized laboratory animals carrying an infectious disease. The isolator system, including the transfer chain, disinfection chain, negative air pressure isolation system, animal welfare system, and the automated system, was designed to meet all biological safety standards. To create an internal chamber environment that was completely isolated from the exterior, variable frequency drive blowers were used in the air-intake and air-exhaust system, precisely controlling the filtered airflow and providing an air-barrier protection. To transfer the material between the interior of the isolation chamber and the outside, a double door transfer port was used. A peracetic acid sterilizer and its affiliated pipeline allowed for a complete disinfection of the isolation chamber. All of the isolator system parameters can be automatically controlled by a programmable computerized menu allowing for work with different animals in different sized cages depending on the research project. The multifunctional isolator system should be a useful safety device for working with medium-sized laboratory infectious animals in high-level biosafety laboratories.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleDevelopment of a Multifunction Isolator System for the Care of Medium-Sized Laboratory Animals Harboring Infectious Diseases
    typeJournal Paper
    journal volume4
    journal issue4
    journal titleJournal of Medical Devices
    identifier doi10.1115/1.4002623
    journal fristpage41004
    identifier eissn1932-619X
    keywordsPressure
    keywordsDoors
    keywordsDiseases
    keywordsExhaust systems
    keywordsScreens (Mining)
    keywordsValves
    keywordsVentilation
    keywordsStainless steel
    keywordsScrews
    keywordsAir flow
    keywordsSterilization AND Safety
    treeJournal of Medical Devices:;2010:;volume( 004 ):;issue: 004
    contenttypeFulltext
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    DSpace software copyright © 2002-2015  DuraSpace
    نرم افزار کتابخانه دیجیتال "دی اسپیس" فارسی شده توسط یابش برای کتابخانه های ایرانی | تماس با یابش
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