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    Cell Crawling Assisted by Contractile Stress Induced Retraction

    Source: Journal of Biomechanical Engineering:;2010:;volume( 132 ):;issue: 006::page 61005
    Author:
    Sitikantha Roy
    ,
    Feng Miao
    ,
    H. Jerry Qi
    DOI: 10.1115/1.4001074
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Cell locomotion is a result of a series of synchronized chemo-mechanical processes. Crawling-type cell locomotion consists of three steps: protrusion, translocation, and retraction. Previous works have shown that both protrusion and retraction can produce cell movement. For the latter, a cell derives its propulsive force from retraction induced protrusion mechanism, which was experimentally verified by (1979, “Induction of Spreading During Fibroblast Movement,” J. Cell Biol., 81, pp. 684–691). In this paper, using finite element method, we take a computational biomimetic approach to study cell crawling assisted by contractile stress induced de-adhesion at the rear of the focal adhesion zone (FAZ). We assume the formation of the FAZ is driven by receptor-ligand bonds and nonspecific interactions. The contractile stress is generated due to the molecular activation of the intracellular actin-myosin machinery. The exerted contractile stress and its time dependency are modeled in a phenomenological manner as a two-spring mechanosensor proposed by (2006, “Focal Adhesions as Mechanosensors: The Two-Spring Model,” BioSystems, 83(2–3), pp. 225–232). Through coupling the kinetics of receptor-ligand bonds with contractile stress, de-adhesion can be achieved when the stall value of the contractile stress is larger than a critical one. De-adhesion at the rear end of the FAZ causes a redistribution of elastic energy and induces cell locomotion. Parametric studies were conducted to investigate the connection between the cell locomotion speed and stall stress, and receptor-ligand kinetics. Finally, we provide a scaling relationship that can be used to estimate the cell locomotion speed.
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      Cell Crawling Assisted by Contractile Stress Induced Retraction

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    contributor authorSitikantha Roy
    contributor authorFeng Miao
    contributor authorH. Jerry Qi
    date accessioned2017-05-09T00:36:35Z
    date available2017-05-09T00:36:35Z
    date copyrightJune, 2010
    date issued2010
    identifier issn0148-0731
    identifier otherJBENDY-27144#061005_1.pdf
    identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/142605
    description abstractCell locomotion is a result of a series of synchronized chemo-mechanical processes. Crawling-type cell locomotion consists of three steps: protrusion, translocation, and retraction. Previous works have shown that both protrusion and retraction can produce cell movement. For the latter, a cell derives its propulsive force from retraction induced protrusion mechanism, which was experimentally verified by (1979, “Induction of Spreading During Fibroblast Movement,” J. Cell Biol., 81, pp. 684–691). In this paper, using finite element method, we take a computational biomimetic approach to study cell crawling assisted by contractile stress induced de-adhesion at the rear of the focal adhesion zone (FAZ). We assume the formation of the FAZ is driven by receptor-ligand bonds and nonspecific interactions. The contractile stress is generated due to the molecular activation of the intracellular actin-myosin machinery. The exerted contractile stress and its time dependency are modeled in a phenomenological manner as a two-spring mechanosensor proposed by (2006, “Focal Adhesions as Mechanosensors: The Two-Spring Model,” BioSystems, 83(2–3), pp. 225–232). Through coupling the kinetics of receptor-ligand bonds with contractile stress, de-adhesion can be achieved when the stall value of the contractile stress is larger than a critical one. De-adhesion at the rear end of the FAZ causes a redistribution of elastic energy and induces cell locomotion. Parametric studies were conducted to investigate the connection between the cell locomotion speed and stall stress, and receptor-ligand kinetics. Finally, we provide a scaling relationship that can be used to estimate the cell locomotion speed.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleCell Crawling Assisted by Contractile Stress Induced Retraction
    typeJournal Paper
    journal volume132
    journal issue6
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.4001074
    journal fristpage61005
    identifier eissn1528-8951
    treeJournal of Biomechanical Engineering:;2010:;volume( 132 ):;issue: 006
    contenttypeFulltext
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    DSpace software copyright © 2002-2015  DuraSpace
    نرم افزار کتابخانه دیجیتال "دی اسپیس" فارسی شده توسط یابش برای کتابخانه های ایرانی | تماس با یابش
    yabeshDSpacePersian