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    Differences in Aortic Arch Geometry, Hemodynamics, and Plaque Patterns Between C57BL/6 and 129/SvEv Mice

    Source: Journal of Biomechanical Engineering:;2009:;volume( 131 ):;issue: 012::page 121005
    Author:
    Hui Zhu
    ,
    John R. Hagaman
    ,
    Morton H. Friedman
    ,
    Nobuyo Maeda
    ,
    Ji Zhang
    ,
    Jessica Shih
    ,
    Federico Lopez-Bertoni
    DOI: 10.1115/1.4000168
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Atherosclerotic plaques are distributed differently in the aortic arches of C57BL/6 (B6) and 129/SvEv (129) apolipoprotein E (apoE)-deficient mice. It is now recognized that hemodynamic wall shear stress (WSS) plays an important role in the localization of atherosclerotic development. Since the blood flow field in the vessel is modulated by the vascular geometry, we quantitatively examined the difference in the aortic arch geometry and hemodynamic WSS between the two corresponding wild-type mouse strains. The three-dimensional (3D) geometry of 14 murine aortic arches, seven from each strain, was characterized using casts and stereo microscopic imaging. Based on the geometry of each cast, an average 3D geometry of the aortic arch for each mouse strain was obtained, and computational fluid dynamic calculations were performed in the two average aortic arches. Many geometric features, including aortic arch shape, vessel diameter, and branch locations, were significantly different at p<0.05 between the two mouse strains. Lower shear stress was found at the inner curvature of the aortic arch in the 129 strain, corresponding to greater involvement in the corresponding apoE-deficient mice relative to the B6 strain. These results support the notion that heritable features of arterial geometry can contribute to individual differences in local susceptibility to arterial disease.
    keyword(s): Arches , Geometry , Hemodynamics , Bifurcation AND Vessels ,
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      Differences in Aortic Arch Geometry, Hemodynamics, and Plaque Patterns Between C57BL/6 and 129/SvEv Mice

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    http://yetl.yabesh.ir/yetl1/handle/yetl/139803
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    contributor authorHui Zhu
    contributor authorJohn R. Hagaman
    contributor authorMorton H. Friedman
    contributor authorNobuyo Maeda
    contributor authorJi Zhang
    contributor authorJessica Shih
    contributor authorFederico Lopez-Bertoni
    date accessioned2017-05-09T00:31:27Z
    date available2017-05-09T00:31:27Z
    date copyrightDecember, 2009
    date issued2009
    identifier issn0148-0731
    identifier otherJBENDY-27079#121005_1.pdf
    identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/139803
    description abstractAtherosclerotic plaques are distributed differently in the aortic arches of C57BL/6 (B6) and 129/SvEv (129) apolipoprotein E (apoE)-deficient mice. It is now recognized that hemodynamic wall shear stress (WSS) plays an important role in the localization of atherosclerotic development. Since the blood flow field in the vessel is modulated by the vascular geometry, we quantitatively examined the difference in the aortic arch geometry and hemodynamic WSS between the two corresponding wild-type mouse strains. The three-dimensional (3D) geometry of 14 murine aortic arches, seven from each strain, was characterized using casts and stereo microscopic imaging. Based on the geometry of each cast, an average 3D geometry of the aortic arch for each mouse strain was obtained, and computational fluid dynamic calculations were performed in the two average aortic arches. Many geometric features, including aortic arch shape, vessel diameter, and branch locations, were significantly different at p<0.05 between the two mouse strains. Lower shear stress was found at the inner curvature of the aortic arch in the 129 strain, corresponding to greater involvement in the corresponding apoE-deficient mice relative to the B6 strain. These results support the notion that heritable features of arterial geometry can contribute to individual differences in local susceptibility to arterial disease.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleDifferences in Aortic Arch Geometry, Hemodynamics, and Plaque Patterns Between C57BL/6 and 129/SvEv Mice
    typeJournal Paper
    journal volume131
    journal issue12
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.4000168
    journal fristpage121005
    identifier eissn1528-8951
    keywordsArches
    keywordsGeometry
    keywordsHemodynamics
    keywordsBifurcation AND Vessels
    treeJournal of Biomechanical Engineering:;2009:;volume( 131 ):;issue: 012
    contenttypeFulltext
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    DSpace software copyright © 2002-2015  DuraSpace
    نرم افزار کتابخانه دیجیتال "دی اسپیس" فارسی شده توسط یابش برای کتابخانه های ایرانی | تماس با یابش
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