Show simple item record

contributor authorZhensong Wei
contributor authorVikram S. Deshpande
contributor authorRobert M. McMeeking
contributor authorAnthony G. Evans
date accessioned2017-05-09T00:27:00Z
date available2017-05-09T00:27:00Z
date copyrightJune, 2008
date issued2008
identifier issn0148-0731
identifier otherJBENDY-26808#031009_1.pdf
identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/137460
description abstractNumerical simulations that incorporate a biochemomechanical model for the contractility of the cytoskeleton have been used to rationalize the following observations. Uniaxial cyclic stretching of cells causes stress fibers to align perpendicular to the stretch direction, with degree of alignment dependent on the stretch strain magnitude, as well as the frequency and the transverse contraction of the substrate. Conversely, equibiaxial cyclic stretching induces a uniform distribution of stress fiber orientations. Demonstrations that the model successfully predicts the alignments experimentally found are followed by a parameter study to investigate the influence of a range of key variables including the stretch magnitude, the intrinsic rate sensitivity of the stress fibers, the straining frequency, and the transverse contraction of the substrate. The primary predictions are as follows. The rate sensitivity has a strong influence on alignment, equivalent to that attained by a few percent of additional stretch. The fiber alignment increases with increasing cycling frequency. Transverse contraction of the substrate causes the stress fibers to organize into two symmetrical orientations with respect to the primary stretch direction.
publisherThe American Society of Mechanical Engineers (ASME)
titleAnalysis and Interpretation of Stress Fiber Organization in Cells Subject to Cyclic Stretch
typeJournal Paper
journal volume130
journal issue3
journal titleJournal of Biomechanical Engineering
identifier doi10.1115/1.2907745
journal fristpage31009
identifier eissn1528-8951
keywordsFibers AND Stress
treeJournal of Biomechanical Engineering:;2008:;volume( 130 ):;issue: 003
contenttypeFulltext


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record