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    Modeling the Mechanics of Tethers Pulled From the Cochlear Outer Hair Cell Membrane

    Source: Journal of Biomechanical Engineering:;2008:;volume( 130 ):;issue: 003::page 31007
    Author:
    Kristopher R. Schumacher
    ,
    Bahman Anvari
    ,
    William E. Brownell
    ,
    Alexander A. Spector
    ,
    Aleksander S. Popel
    DOI: 10.1115/1.2907758
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Cell membrane tethers are formed naturally (e.g., in leukocyte rolling) and experimentally to probe membrane properties. In cochlear outer hair cells, the plasma membrane is part of the trilayer lateral wall, where the membrane is attached to the cytoskeleton by a system of radial pillars. The mechanics of these cells is important to the sound amplification and frequency selectivity of the ear. We present a modeling study to simulate the membrane deflection, bending, and interaction with the cytoskeleton in the outer hair cell tether pulling experiment. In our analysis, three regions of the membrane are considered: the body of a cylindrical tether, the area where the membrane is attached and interacts with the cytoskeleton, and the transition region between the two. By using a computational method, we found the shape of the membrane in all three regions over a range of tether lengths and forces observed in experiments. We also analyze the effects of biophysical properties of the membrane, including the bending modulus and the forces of the membrane adhesion to the cytoskeleton. The model’s results provide a better understanding of the mechanics of tethers pulled from cell membranes.
    keyword(s): Force , Columns (Structural) , Membranes , Plasmas (Ionized gases) AND Deflection ,
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      Modeling the Mechanics of Tethers Pulled From the Cochlear Outer Hair Cell Membrane

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    http://yetl.yabesh.ir/yetl1/handle/yetl/137458
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    contributor authorKristopher R. Schumacher
    contributor authorBahman Anvari
    contributor authorWilliam E. Brownell
    contributor authorAlexander A. Spector
    contributor authorAleksander S. Popel
    date accessioned2017-05-09T00:27:00Z
    date available2017-05-09T00:27:00Z
    date copyrightJune, 2008
    date issued2008
    identifier issn0148-0731
    identifier otherJBENDY-26808#031007_1.pdf
    identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/137458
    description abstractCell membrane tethers are formed naturally (e.g., in leukocyte rolling) and experimentally to probe membrane properties. In cochlear outer hair cells, the plasma membrane is part of the trilayer lateral wall, where the membrane is attached to the cytoskeleton by a system of radial pillars. The mechanics of these cells is important to the sound amplification and frequency selectivity of the ear. We present a modeling study to simulate the membrane deflection, bending, and interaction with the cytoskeleton in the outer hair cell tether pulling experiment. In our analysis, three regions of the membrane are considered: the body of a cylindrical tether, the area where the membrane is attached and interacts with the cytoskeleton, and the transition region between the two. By using a computational method, we found the shape of the membrane in all three regions over a range of tether lengths and forces observed in experiments. We also analyze the effects of biophysical properties of the membrane, including the bending modulus and the forces of the membrane adhesion to the cytoskeleton. The model’s results provide a better understanding of the mechanics of tethers pulled from cell membranes.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleModeling the Mechanics of Tethers Pulled From the Cochlear Outer Hair Cell Membrane
    typeJournal Paper
    journal volume130
    journal issue3
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.2907758
    journal fristpage31007
    identifier eissn1528-8951
    keywordsForce
    keywordsColumns (Structural)
    keywordsMembranes
    keywordsPlasmas (Ionized gases) AND Deflection
    treeJournal of Biomechanical Engineering:;2008:;volume( 130 ):;issue: 003
    contenttypeFulltext
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