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    Computational Model for the Transition From Peristaltic to Pulsatile Flow in the Embryonic Heart Tube

    Source: Journal of Biomechanical Engineering:;2007:;volume( 129 ):;issue: 003::page 441
    Author:
    Larry A. Taber
    ,
    Jinmei Zhang
    ,
    Renato Perucchio
    DOI: 10.1115/1.2721076
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Early in development, the heart is a single muscle-wrapped tube without formed valves. Yet survival of the embryo depends on the ability of this tube to pump blood at steadily increasing rates and pressures. Developmental biologists historically have speculated that the heart tube pumps via a peristaltic mechanism, with a wave of contraction propagating from the inflow to the outflow end. Physiological measurements, however, have shown that the flow becomes pulsatile in character quite early in development, before the valves form. Here, we use a computational model for flow though the embryonic heart to explore the pumping mechanism. Results from the model show that endocardial cushions, which are valve primordia arising near the ends of the tube, induce a transition from peristaltic to pulsatile flow. Comparison of numerical results with published experimental data shows reasonably good agreement for various pressure and flow parameters. This study illustrates the interrelationship between form and function in the early embryonic heart.
    keyword(s): Pressure , Flow (Dynamics) , Waves , Pulsatile flow , Blood , Outflow , Valves , Wavelength , Inflow AND Pumps ,
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      Computational Model for the Transition From Peristaltic to Pulsatile Flow in the Embryonic Heart Tube

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    http://yetl.yabesh.ir/yetl1/handle/yetl/135264
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    • Journal of Biomechanical Engineering

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    contributor authorLarry A. Taber
    contributor authorJinmei Zhang
    contributor authorRenato Perucchio
    date accessioned2017-05-09T00:22:47Z
    date available2017-05-09T00:22:47Z
    date copyrightJune, 2007
    date issued2007
    identifier issn0148-0731
    identifier otherJBENDY-26706#441_1.pdf
    identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/135264
    description abstractEarly in development, the heart is a single muscle-wrapped tube without formed valves. Yet survival of the embryo depends on the ability of this tube to pump blood at steadily increasing rates and pressures. Developmental biologists historically have speculated that the heart tube pumps via a peristaltic mechanism, with a wave of contraction propagating from the inflow to the outflow end. Physiological measurements, however, have shown that the flow becomes pulsatile in character quite early in development, before the valves form. Here, we use a computational model for flow though the embryonic heart to explore the pumping mechanism. Results from the model show that endocardial cushions, which are valve primordia arising near the ends of the tube, induce a transition from peristaltic to pulsatile flow. Comparison of numerical results with published experimental data shows reasonably good agreement for various pressure and flow parameters. This study illustrates the interrelationship between form and function in the early embryonic heart.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleComputational Model for the Transition From Peristaltic to Pulsatile Flow in the Embryonic Heart Tube
    typeJournal Paper
    journal volume129
    journal issue3
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.2721076
    journal fristpage441
    journal lastpage449
    identifier eissn1528-8951
    keywordsPressure
    keywordsFlow (Dynamics)
    keywordsWaves
    keywordsPulsatile flow
    keywordsBlood
    keywordsOutflow
    keywordsValves
    keywordsWavelength
    keywordsInflow AND Pumps
    treeJournal of Biomechanical Engineering:;2007:;volume( 129 ):;issue: 003
    contenttypeFulltext
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