Influence of Decorin and Biglycan on Mechanical Properties of Multiple Tendons in Knockout MiceSource: Journal of Biomechanical Engineering:;2005:;volume( 127 ):;issue: 001::page 181Author:Paul S. Robinson
,
Tung-Fu Huang
,
Elan Kazam
,
Renato V. Iozzo
,
Louis J. Soslowsky
,
David E. Birk
DOI: 10.1115/1.1835363Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Evaluations of tendon mechanical behavior based on biochemical and structural arrangement have implications for designing tendon specific treatment modalities or replacement strategies. In addition to the well studied type I collagen, other important constituents of tendon are the small proteoglycans (PGs). PGs have been shown to vary in concentration within differently loaded areas of tendon, implicating them in specific tendon function. This study measured the mechanical properties of multiple tendon tissues from normal mice and from mice with knock-outs of the PGs decorin or biglycan. Tail tendon fascicles, patellar tendons (PT), and flexor digitorum longus tendons (FDL), three tissues representing different in vivo loading environments, were characterized from the three groups of mice. It was hypothesized that the absence of decorin or biglycan would have individual effects on each type of tendon tissue. Surprisingly, no change in mechanical properties was observed for the tail tendon fascicles due to the PG knockouts. The loss of decorin affected the PT, causing an increase in modulus and stress relaxation, but had little effect on the FDL. Conversely, the loss of biglycan did not significantly affect the PT, but caused a reduction in both the maximum stress and modulus of the FDL. These results give mechanical support to previous biochemical data that tendons likely are uniquely tailored to their specific location and function. Variances such as those presented here need to be further characterized and taken into account when designing therapies or replacements for any one particular tendon.
keyword(s): Relaxation (Physics) , Stress , Mechanical properties , Biological tissues AND Tendons ,
|
Collections
Show full item record
contributor author | Paul S. Robinson | |
contributor author | Tung-Fu Huang | |
contributor author | Elan Kazam | |
contributor author | Renato V. Iozzo | |
contributor author | Louis J. Soslowsky | |
contributor author | David E. Birk | |
date accessioned | 2017-05-09T00:15:27Z | |
date available | 2017-05-09T00:15:27Z | |
date copyright | February, 2005 | |
date issued | 2005 | |
identifier issn | 0148-0731 | |
identifier other | JBENDY-26445#181_1.pdf | |
identifier uri | http://yetl.yabesh.ir/yetl/handle/yetl/131444 | |
description abstract | Evaluations of tendon mechanical behavior based on biochemical and structural arrangement have implications for designing tendon specific treatment modalities or replacement strategies. In addition to the well studied type I collagen, other important constituents of tendon are the small proteoglycans (PGs). PGs have been shown to vary in concentration within differently loaded areas of tendon, implicating them in specific tendon function. This study measured the mechanical properties of multiple tendon tissues from normal mice and from mice with knock-outs of the PGs decorin or biglycan. Tail tendon fascicles, patellar tendons (PT), and flexor digitorum longus tendons (FDL), three tissues representing different in vivo loading environments, were characterized from the three groups of mice. It was hypothesized that the absence of decorin or biglycan would have individual effects on each type of tendon tissue. Surprisingly, no change in mechanical properties was observed for the tail tendon fascicles due to the PG knockouts. The loss of decorin affected the PT, causing an increase in modulus and stress relaxation, but had little effect on the FDL. Conversely, the loss of biglycan did not significantly affect the PT, but caused a reduction in both the maximum stress and modulus of the FDL. These results give mechanical support to previous biochemical data that tendons likely are uniquely tailored to their specific location and function. Variances such as those presented here need to be further characterized and taken into account when designing therapies or replacements for any one particular tendon. | |
publisher | The American Society of Mechanical Engineers (ASME) | |
title | Influence of Decorin and Biglycan on Mechanical Properties of Multiple Tendons in Knockout Mice | |
type | Journal Paper | |
journal volume | 127 | |
journal issue | 1 | |
journal title | Journal of Biomechanical Engineering | |
identifier doi | 10.1115/1.1835363 | |
journal fristpage | 181 | |
journal lastpage | 185 | |
identifier eissn | 1528-8951 | |
keywords | Relaxation (Physics) | |
keywords | Stress | |
keywords | Mechanical properties | |
keywords | Biological tissues AND Tendons | |
tree | Journal of Biomechanical Engineering:;2005:;volume( 127 ):;issue: 001 | |
contenttype | Fulltext |