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    Influence of Decorin and Biglycan on Mechanical Properties of Multiple Tendons in Knockout Mice

    Source: Journal of Biomechanical Engineering:;2005:;volume( 127 ):;issue: 001::page 181
    Author:
    Paul S. Robinson
    ,
    Tung-Fu Huang
    ,
    Elan Kazam
    ,
    Renato V. Iozzo
    ,
    Louis J. Soslowsky
    ,
    David E. Birk
    DOI: 10.1115/1.1835363
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Evaluations of tendon mechanical behavior based on biochemical and structural arrangement have implications for designing tendon specific treatment modalities or replacement strategies. In addition to the well studied type I collagen, other important constituents of tendon are the small proteoglycans (PGs). PGs have been shown to vary in concentration within differently loaded areas of tendon, implicating them in specific tendon function. This study measured the mechanical properties of multiple tendon tissues from normal mice and from mice with knock-outs of the PGs decorin or biglycan. Tail tendon fascicles, patellar tendons (PT), and flexor digitorum longus tendons (FDL), three tissues representing different in vivo loading environments, were characterized from the three groups of mice. It was hypothesized that the absence of decorin or biglycan would have individual effects on each type of tendon tissue. Surprisingly, no change in mechanical properties was observed for the tail tendon fascicles due to the PG knockouts. The loss of decorin affected the PT, causing an increase in modulus and stress relaxation, but had little effect on the FDL. Conversely, the loss of biglycan did not significantly affect the PT, but caused a reduction in both the maximum stress and modulus of the FDL. These results give mechanical support to previous biochemical data that tendons likely are uniquely tailored to their specific location and function. Variances such as those presented here need to be further characterized and taken into account when designing therapies or replacements for any one particular tendon.
    keyword(s): Relaxation (Physics) , Stress , Mechanical properties , Biological tissues AND Tendons ,
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      Influence of Decorin and Biglycan on Mechanical Properties of Multiple Tendons in Knockout Mice

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    contributor authorPaul S. Robinson
    contributor authorTung-Fu Huang
    contributor authorElan Kazam
    contributor authorRenato V. Iozzo
    contributor authorLouis J. Soslowsky
    contributor authorDavid E. Birk
    date accessioned2017-05-09T00:15:27Z
    date available2017-05-09T00:15:27Z
    date copyrightFebruary, 2005
    date issued2005
    identifier issn0148-0731
    identifier otherJBENDY-26445#181_1.pdf
    identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/131444
    description abstractEvaluations of tendon mechanical behavior based on biochemical and structural arrangement have implications for designing tendon specific treatment modalities or replacement strategies. In addition to the well studied type I collagen, other important constituents of tendon are the small proteoglycans (PGs). PGs have been shown to vary in concentration within differently loaded areas of tendon, implicating them in specific tendon function. This study measured the mechanical properties of multiple tendon tissues from normal mice and from mice with knock-outs of the PGs decorin or biglycan. Tail tendon fascicles, patellar tendons (PT), and flexor digitorum longus tendons (FDL), three tissues representing different in vivo loading environments, were characterized from the three groups of mice. It was hypothesized that the absence of decorin or biglycan would have individual effects on each type of tendon tissue. Surprisingly, no change in mechanical properties was observed for the tail tendon fascicles due to the PG knockouts. The loss of decorin affected the PT, causing an increase in modulus and stress relaxation, but had little effect on the FDL. Conversely, the loss of biglycan did not significantly affect the PT, but caused a reduction in both the maximum stress and modulus of the FDL. These results give mechanical support to previous biochemical data that tendons likely are uniquely tailored to their specific location and function. Variances such as those presented here need to be further characterized and taken into account when designing therapies or replacements for any one particular tendon.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleInfluence of Decorin and Biglycan on Mechanical Properties of Multiple Tendons in Knockout Mice
    typeJournal Paper
    journal volume127
    journal issue1
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.1835363
    journal fristpage181
    journal lastpage185
    identifier eissn1528-8951
    keywordsRelaxation (Physics)
    keywordsStress
    keywordsMechanical properties
    keywordsBiological tissues AND Tendons
    treeJournal of Biomechanical Engineering:;2005:;volume( 127 ):;issue: 001
    contenttypeFulltext
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    DSpace software copyright © 2002-2015  DuraSpace
    نرم افزار کتابخانه دیجیتال "دی اسپیس" فارسی شده توسط یابش برای کتابخانه های ایرانی | تماس با یابش
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