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    A Model for Mechanics of Primary Lymphatic Valves

    Source: Journal of Biomechanical Engineering:;2003:;volume( 125 ):;issue: 003::page 407
    Author:
    Ernesto Mendoza
    ,
    Geert W. Schmid-Schönbein
    DOI: 10.1115/1.1568128
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Recent experimental evidence indicates that lymphatics have two valve systems, a set of primary valves in the wall of the endothelial cells of initial lymphatics and a secondary valve system in the lumen of the lymphatics. While the intralymphatic secondary valves are well described, no analysis of the primary valves is available. We propose a model for primary lymphatics valves at the junctions between lymphatic endothelial cells. The model consists of two overlapping endothelial extensions at a cell junction in the initial lymphatics. One cell extension is firmly attached to the adjacent connective tissue while the other cell extension is not attached to the interstitial collagen. It is free to bend into the lumen of the lymphatic when the lymphatic pressure falls below the adjacent interstitial fluid pressure. Thereby the cell junction opens a gap permitting entry of interstitial fluid into the lymphatic lumen. When the lymphatic fluid pressure rises above the adjacent interstitial fluid pressure, the endothelial extensions contact each other and the junction is closed preventing fluid reflow into the interstitial space. The model illustrates the mechanics of valve action and provides the first time a rational analysis of the mechanisms underlying fluid collection in the initial lymphatics and lymph transport in the microcirculation.
    keyword(s): Fluids , Biological tissues , Valves , Junctions , Endothelial cells , Pressure AND Fluid pressure ,
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      A Model for Mechanics of Primary Lymphatic Valves

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    http://yetl.yabesh.ir/yetl1/handle/yetl/127992
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    • Journal of Biomechanical Engineering

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    contributor authorErnesto Mendoza
    contributor authorGeert W. Schmid-Schönbein
    date accessioned2017-05-09T00:09:32Z
    date available2017-05-09T00:09:32Z
    date copyrightJune, 2003
    date issued2003
    identifier issn0148-0731
    identifier otherJBENDY-26322#407_1.pdf
    identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/127992
    description abstractRecent experimental evidence indicates that lymphatics have two valve systems, a set of primary valves in the wall of the endothelial cells of initial lymphatics and a secondary valve system in the lumen of the lymphatics. While the intralymphatic secondary valves are well described, no analysis of the primary valves is available. We propose a model for primary lymphatics valves at the junctions between lymphatic endothelial cells. The model consists of two overlapping endothelial extensions at a cell junction in the initial lymphatics. One cell extension is firmly attached to the adjacent connective tissue while the other cell extension is not attached to the interstitial collagen. It is free to bend into the lumen of the lymphatic when the lymphatic pressure falls below the adjacent interstitial fluid pressure. Thereby the cell junction opens a gap permitting entry of interstitial fluid into the lymphatic lumen. When the lymphatic fluid pressure rises above the adjacent interstitial fluid pressure, the endothelial extensions contact each other and the junction is closed preventing fluid reflow into the interstitial space. The model illustrates the mechanics of valve action and provides the first time a rational analysis of the mechanisms underlying fluid collection in the initial lymphatics and lymph transport in the microcirculation.
    publisherThe American Society of Mechanical Engineers (ASME)
    titleA Model for Mechanics of Primary Lymphatic Valves
    typeJournal Paper
    journal volume125
    journal issue3
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.1568128
    journal fristpage407
    journal lastpage414
    identifier eissn1528-8951
    keywordsFluids
    keywordsBiological tissues
    keywordsValves
    keywordsJunctions
    keywordsEndothelial cells
    keywordsPressure AND Fluid pressure
    treeJournal of Biomechanical Engineering:;2003:;volume( 125 ):;issue: 003
    contenttypeFulltext
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