Mechanism of Incomplete Mitral Leaflet Coaptation—Interaction of Chordal Restraint and Changes in Mitral Leaflet Coaptation Geometry: Insight from In Vitro Validation of the Premise of Force EquilibriumSource: Journal of Biomechanical Engineering:;2002:;volume( 124 ):;issue: 005::page 596Author:Sten Lyager Nielsen
,
Hans Nygaard
,
Lars Mandrup
,
Arnold A. Fontaine
,
J. Michael Hasenkam
,
Shengqui He
,
Ajit P. Yoganathan
DOI: 10.1115/1.1500741Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Clinically observed incomplete mitral leaflet coaptation was reproduced in vitro by altering the balance of the chordal tethering and chordal coapting force components. Mitral leaflet coaptation geometry was distorted by changes of the spatial relations between the papillary muscles and the mitral valve as well as hemodynamics. Mitral leaflet malalignment was accentuated by a redistribution of the chordal tethering and coapting force components. For the overall assessment of systolic mitral leaflet configuration in functional mitral regurgitation it is important to consider the interaction between chordal restraint and an altered mitral leaflet coaptation geometry.
keyword(s): Force , Equilibrium (Physics) , Valves , Geometry , Muscle AND Displacement ,
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| contributor author | Sten Lyager Nielsen | |
| contributor author | Hans Nygaard | |
| contributor author | Lars Mandrup | |
| contributor author | Arnold A. Fontaine | |
| contributor author | J. Michael Hasenkam | |
| contributor author | Shengqui He | |
| contributor author | Ajit P. Yoganathan | |
| date accessioned | 2017-05-09T00:06:48Z | |
| date available | 2017-05-09T00:06:48Z | |
| date copyright | October, 2002 | |
| date issued | 2002 | |
| identifier issn | 0148-0731 | |
| identifier other | JBENDY-26269#596_1.pdf | |
| identifier uri | http://yetl.yabesh.ir/yetl/handle/yetl/126368 | |
| description abstract | Clinically observed incomplete mitral leaflet coaptation was reproduced in vitro by altering the balance of the chordal tethering and chordal coapting force components. Mitral leaflet coaptation geometry was distorted by changes of the spatial relations between the papillary muscles and the mitral valve as well as hemodynamics. Mitral leaflet malalignment was accentuated by a redistribution of the chordal tethering and coapting force components. For the overall assessment of systolic mitral leaflet configuration in functional mitral regurgitation it is important to consider the interaction between chordal restraint and an altered mitral leaflet coaptation geometry. | |
| publisher | The American Society of Mechanical Engineers (ASME) | |
| title | Mechanism of Incomplete Mitral Leaflet Coaptation—Interaction of Chordal Restraint and Changes in Mitral Leaflet Coaptation Geometry: Insight from In Vitro Validation of the Premise of Force Equilibrium | |
| type | Journal Paper | |
| journal volume | 124 | |
| journal issue | 5 | |
| journal title | Journal of Biomechanical Engineering | |
| identifier doi | 10.1115/1.1500741 | |
| journal fristpage | 596 | |
| journal lastpage | 608 | |
| identifier eissn | 1528-8951 | |
| keywords | Force | |
| keywords | Equilibrium (Physics) | |
| keywords | Valves | |
| keywords | Geometry | |
| keywords | Muscle AND Displacement | |
| tree | Journal of Biomechanical Engineering:;2002:;volume( 124 ):;issue: 005 | |
| contenttype | Fulltext |