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    Surfactant Transport Over Airway Liquid Lining of Nonuniform Depth

    Source: Journal of Biomechanical Engineering:;2000:;volume( 122 ):;issue: 002::page 159
    Author:
    H. A. R. Williams
    ,
    O. E. Jensen
    DOI: 10.1115/1.429637
    Publisher: The American Society of Mechanical Engineers (ASME)
    Abstract: Numerous effects (e.g., airway wall buckling, gravity, airway curvature, capillary instabilities) give rise to nonuniformities in the depth of the liquid lining of peripheral lung airways. The effects of such thickness variations on the unsteady spreading of a surfactant monolayer along an airway are explored theoretically here. Flow-induced film deformations are shown to have only a modest influence on spreading rates, motivating the use of a simplified model in which the liquid-lining depth is prescribed and the monolayer concentration satisfies a spatially inhomogeneous nonlinear diffusion equation. Two generic situations are considered: spreading along a continuous annular liquid lining of nonuniform depth, and spreading along a rivulet that wets the airway wall with zero contact angle. In both cases, transverse averaging at large times yields a one-dimensional approximation of axial spreading that is valid for the majority of the monolayer. However, a localized monolayer remains persistently two dimensional in a region at its leading edge having axial length scales comparable to the length scale of transverse depth variation. It is also shown how the transverse spreading of a monolayer may be arrested as it approaches a static contact line at the edge of a rivulet. Implications for Surfactant Replacement Therapy are discussed. [S0148-0731(00)00202-8]
    keyword(s): Flow (Dynamics) , Linings (Textiles) , Surfactants , Deformation , Diffusion (Physics) , Gradients , Thickness , Channels (Hydraulic engineering) , Approximation , Equations AND Gravity (Force) ,
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      Surfactant Transport Over Airway Liquid Lining of Nonuniform Depth

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    http://yetl.yabesh.ir/yetl1/handle/yetl/123385
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    contributor authorH. A. R. Williams
    contributor authorO. E. Jensen
    date accessioned2017-05-09T00:01:54Z
    date available2017-05-09T00:01:54Z
    date copyrightApril, 2000
    date issued2000
    identifier issn0148-0731
    identifier otherJBENDY-25900#159_1.pdf
    identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/123385
    description abstractNumerous effects (e.g., airway wall buckling, gravity, airway curvature, capillary instabilities) give rise to nonuniformities in the depth of the liquid lining of peripheral lung airways. The effects of such thickness variations on the unsteady spreading of a surfactant monolayer along an airway are explored theoretically here. Flow-induced film deformations are shown to have only a modest influence on spreading rates, motivating the use of a simplified model in which the liquid-lining depth is prescribed and the monolayer concentration satisfies a spatially inhomogeneous nonlinear diffusion equation. Two generic situations are considered: spreading along a continuous annular liquid lining of nonuniform depth, and spreading along a rivulet that wets the airway wall with zero contact angle. In both cases, transverse averaging at large times yields a one-dimensional approximation of axial spreading that is valid for the majority of the monolayer. However, a localized monolayer remains persistently two dimensional in a region at its leading edge having axial length scales comparable to the length scale of transverse depth variation. It is also shown how the transverse spreading of a monolayer may be arrested as it approaches a static contact line at the edge of a rivulet. Implications for Surfactant Replacement Therapy are discussed. [S0148-0731(00)00202-8]
    publisherThe American Society of Mechanical Engineers (ASME)
    titleSurfactant Transport Over Airway Liquid Lining of Nonuniform Depth
    typeJournal Paper
    journal volume122
    journal issue2
    journal titleJournal of Biomechanical Engineering
    identifier doi10.1115/1.429637
    journal fristpage159
    journal lastpage165
    identifier eissn1528-8951
    keywordsFlow (Dynamics)
    keywordsLinings (Textiles)
    keywordsSurfactants
    keywordsDeformation
    keywordsDiffusion (Physics)
    keywordsGradients
    keywordsThickness
    keywordsChannels (Hydraulic engineering)
    keywordsApproximation
    keywordsEquations AND Gravity (Force)
    treeJournal of Biomechanical Engineering:;2000:;volume( 122 ):;issue: 002
    contenttypeFulltext
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    DSpace software copyright © 2002-2015  DuraSpace
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