Abstract: Nanoparticle-mediated drug delivery may be a promising alternative to traditional chemotherapy of high systemic toxicity. Tumor tissue architecture poses a challenge to delivery of nanoparticles. Small and spherical ...

Abstract: Nanoparticle drug delivery better targets neoplastic lesions than free drugs and thus has emerged as a safer form of cancer therapy. Nanoparticle design variables are important determinants of efficacy as they influence ...

Abstract: Previous work in air transportation system-of-systems (ATSoSs) design optimization considered integrated aircraft sizing, fleet allocation, and route network configuration. The associated nested multidisciplinary formulation ...

Abstract: Nanoparticle (NP)-based drug delivery is a promising method to increase the therapeutic index of anticancer agents with low median toxic dose. The delivery efficiency, corresponding to the fraction of the injected NPs that ...

Abstract: Typical challenges of simulationbased design optimization include unavailable gradients and unreliable approximations thereof, expensive function evaluations, numerical noise, multiple local optima, and the failure of the ...

Abstract: Static structural aeroengine components are typically designed for full lifetime operation. Under this assumption, efforts to reduce weight in order to improve the performance result in structural designs that necessitate ...

Abstract: Design space exploration and margin analysis can inform critical decisions early in engineering design, helping to handle the uncertainties of early design while ensuring design performance. In practice, the complexity of ...

Abstract: Computational simulation models support a rapid design process. Given model approximation and operating conditions uncertainty, designers must have confidence that the designs obtained using simulations will perform as ...

Abstract: This paper presents a method for design optimization of brass wind instruments. The shape of a trumpet's bore is optimized to improve intonation using a physics-based sound simulation model. This physics-based model consists ...