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contributor authorKang, Shengzheng
contributor authorSong, Zhicheng
contributor authorYang, Xiaolong
contributor authorLi, Yao
contributor authorWu, Hongtao
contributor authorLi, Tao
date accessioned2023-11-29T19:06:53Z
date available2023-11-29T19:06:53Z
date copyright5/22/2023 12:00:00 AM
date issued5/22/2023 12:00:00 AM
date issued2023-05-22
identifier issn0148-0731
identifier otherbio_145_09_091007.pdf
identifier urihttp://yetl.yabesh.ir/yetl1/handle/yetl/4294589
description abstractAs an effective method to deliver external materials into biological cells, microinjection has been widely applied in the biomedical field. However, the knowledge of cell mechanical property is still inadequate, which greatly limits the efficiency and success rate of injection. Thus, a new rate-dependent mechanical model based on membrane theory is proposed for the first time. In this model, an analytical equilibrium equation between the injection force and cell deformation is established by considering the speed effect of microinjection. Different from the traditional membrane-theory-based model, the elastic coefficient of the constitutive material in the proposed model is modified as a function of the injection velocity and acceleration, effectively simulating the influence of speeds on the mechanical responses and providing a more generalized and practical model. Using this model, other mechanical responses at different speeds can be also accurately predicted, including the distribution of membrane tension and stress and the deformed shape. To verify the validity of the model, numerical simulations and experiments were carried out. The results show that the proposed model can match the real mechanical responses well at different injection speeds up to 2 mm/s. The model presented in this paper will be promising in the application of automatic batch cell microinjection with high efficiency.
publisherThe American Society of Mechanical Engineers (ASME)
titleA Rate-Dependent Cell Microinjection Model Based on Membrane Theory
typeJournal Paper
journal volume145
journal issue9
journal titleJournal of Biomechanical Engineering
identifier doi10.1115/1.4062422
journal fristpage91007-1
journal lastpage91007-11
page11
treeJournal of Biomechanical Engineering:;2023:;volume( 145 ):;issue: 009
contenttypeFulltext


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