Show simple item record

contributor authorCampbell, Jennifer
contributor authorMcGuinness, Ian
contributor authorWirz, Holger
contributor authorSharon, Andre
contributor authorSauer
date accessioned2017-05-09T01:22:12Z
date available2017-05-09T01:22:12Z
date issued2015
identifier issn1949-2944
identifier othernano_006_02_021005.pdf
identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/159265
description abstractWe have developed a threedimensional (3D) bioprinting system capable of multimaterial and multiscale deposition to enable the next generation of “bottomupâ€‌ tissue engineering. This area of research resides at the interface of engineering and life sciences. As such, it entails the design and implementation of diverse elements: a novel hydrogelbased bioink, a 3D bioprinter, automation software, and mammalian cell culture. Our bioprinter has three components uniquely combined into a comprehensive tool: syringe pumps connected to a selector valve that allow precise application of up to five different materials with varying viscosities and chemistries, a high velocity/highprecision x–y–z stage to accommodate the most rapid speeds allowable by the printed materials, and temperature control of the bioink reservoirs, lines, and printing environment. Our customdesigned bioprinter is able to print multiple materials (or multiple cell types in the same material) concurrently with various feature sizes (100 خ¼m–1 mm wide; 100 خ¼m–1 cm high). One of these materials is a biocompatible, printable bioink that has been used to test for cell survival within the hydrogel following printing. Handprinted (HP) controls show that our bioprinter does not adversely affect the viability of the printed cells. Here, we report the design and build of the 3D bioprinter, the optimization of the bioink, and the stability and viability of our printed constructs.
publisherThe American Society of Mechanical Engineers (ASME)
titleMultimaterial and Multiscale Three Dimensional Bioprinter
typeJournal Paper
journal volume6
journal issue2
journal titleJournal of Nanotechnology in Engineering and Medicine
identifier doi10.1115/1.4031230
journal fristpage21005
journal lastpage21005
identifier eissn1949-2952
treeJournal of Nanotechnology in Engineering and Medicine:;2015:;volume( 006 ):;issue: 002
contenttypeFulltext


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record