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contributor authorAdnan Qamar
contributor authorZheng Z. Wong
contributor authorJ. Brian Fowlkes
contributor authorJoseph L. Bull
date accessioned2017-05-09T00:48:34Z
date available2017-05-09T00:48:34Z
date copyrightMarch, 2012
date issued2012
identifier issn0148-0731
identifier otherJBENDY-28991#031010_1.pdf
identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/148281
description abstractAcoustic vaporization dynamics of a superheated dodecafluoropentane (DDFP) microdroplet inside a microtube and the resulting bubble evolution is investigated in the present work. This work is motivated by a developmental gas embolotherapy technique that is intended to treat cancers by infarcting tumors using gas bubbles. A combined theoretical and computational approach is utilized and compared with the experiments to understand the evolution process and to estimate the resulting stress distribution associated with vaporization event. The transient bubble growth is first studied by ultra-high speed imaging and then theoretical and computational modeling is used to predict the entire bubble evolution process. The evolution process consists of three regimes: an initial linear rapid spherical growth followed by a linear compressed oval shaped growth and finally a slow asymptotic nonlinear spherical bubble growth. Although the droplets are small compared to the tube diameter, the bubble evolution is influenced by the tube wall. The final bubble radius is found to scale linearly with the initial droplet radius and is approximately five times the initial droplet radius. A short pressure pulse with amplitude almost twice as that of ambient conditions is observed. The width of this pressure pulse increases with increasing droplet size whereas the amplitude is weakly dependent. Although the rise in shear stress along the tube wall is found to be under peak physiological limits, the shear stress amplitude is found to be more prominently influenced by the initial droplet size. The role of viscous dissipation along the tube wall and ambient bulk fluid pressure is found to be significant in bubble evolution dynamics.
publisherThe American Society of Mechanical Engineers (ASME)
titleEvolution of Acoustically Vaporized Microdroplets in Gas Embolotherapy
typeJournal Paper
journal volume134
journal issue3
journal titleJournal of Biomechanical Engineering
identifier doi10.1115/1.4005980
journal fristpage31010
identifier eissn1528-8951
keywordsPressure
keywordsAcoustics
keywordsBubbles
keywordsStress
keywordsDynamics (Mechanics) AND Energy dissipation
treeJournal of Biomechanical Engineering:;2012:;volume( 134 ):;issue: 003
contenttypeFulltext


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