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contributor authorJohn F. LaDisa
contributor authorC. Alberto Figueroa
contributor authorIrene E. Vignon-Clementel
contributor authorHyun Jin Kim
contributor authorNan Xiao
contributor authorLaura M. Ellwein
contributor authorFrandics P. Chan
contributor authorJeffrey A. Feinstein
contributor authorCharles A. Taylor
date accessioned2017-05-09T00:42:22Z
date available2017-05-09T00:42:22Z
date copyrightSeptember, 2011
date issued2011
identifier issn0148-0731
identifier otherJBENDY-27218#091008_1.pdf
identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/145384
description abstractTreatments for coarctation of the aorta (CoA) can alleviate blood pressure (BP) gradients (Δ), but long-term morbidity still exists that can be explained by altered indices of hemodynamics and biomechanics. We introduce a technique to increase our understanding of these indices for CoA under resting and nonresting conditions, quantify their contribution to morbidity, and evaluate treatment options. Patient-specific computational fluid dynamics (CFD) models were created from imaging and BP data for one normal and four CoA patients (moderate native CoA: Δ12 mmHg, severe native CoA: Δ25 mmHg and postoperative end-to-end and end-to-side patients: Δ0 mmHg). Simulations incorporated vessel deformation, downstream vascular resistance and compliance. Indices including cyclic strain, time-averaged wall shear stress (TAWSS), and oscillatory shear index (OSI) were quantified. Simulations replicated resting BP and blood flow data. BP during simulated exercise for the normal patient matched reported values. Greatest exercise-induced increases in systolic BP and mean and peak ΔBP occurred for the moderate native CoA patient (SBP: 115 to 154 mmHg; mean and peak ΔBP: 31 and 73 mmHg). Cyclic strain was elevated proximal to the coarctation for native CoA patients, but reduced throughout the aorta after treatment. A greater percentage of vessels was exposed to subnormal TAWSS or elevated OSI for CoA patients. Local patterns of these indices reported to correlate with atherosclerosis in normal patients were accentuated by CoA. These results apply CFD to a range of CoA patients for the first time and provide the foundation for future progress in this area.
publisherThe American Society of Mechanical Engineers (ASME)
titleComputational Simulations for Aortic Coarctation: Representative Results From a Sampling of Patients
typeJournal Paper
journal volume133
journal issue9
journal titleJournal of Biomechanical Engineering
identifier doi10.1115/1.4004996
journal fristpage91008
identifier eissn1528-8951
keywordsComputational fluid dynamics
keywordsEngineering simulation
keywordsHemodynamics
keywordsVessels
keywordsAorta
keywordsBlood flow
keywordsBoundary-value problems
keywordsMagnetic resonance imaging
keywordsImaging
keywordsEquipment and tools
keywordsGradients AND Bifurcation
treeJournal of Biomechanical Engineering:;2011:;volume( 133 ):;issue: 009
contenttypeFulltext


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