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contributor authorMatthew F. Koff
contributor authorLe Roy Chong
contributor authorPatrick Virtue
contributor authorDan Chen
contributor authorHollis G. Potter
contributor authorXioanan Wang
contributor authorTimothy Wright
date accessioned2017-05-09T00:36:39Z
date available2017-05-09T00:36:39Z
date copyrightApril, 2010
date issued2010
identifier issn0148-0731
identifier otherJBENDY-27127#041007_1.pdf
identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/142637
description abstractDifferent methods have been used to cross-validate cartilage thickness measurements from magnetic resonance images (MRIs); however, a majority of these methods rely on interpolated data points, regional mean and/or maximal thickness, or surface mean thickness for data analysis. Furthermore, the accuracy of MRI cartilage thickness measurements from commercially available software packages has not necessarily been validated and may lead to an under- or overestimation of cartilage thickness. The goal of this study was to perform a matching point-to-point validation of indirect cartilage thickness calculations using a magnetic resonance (MR) image data set with direct cartilage thickness measurements using biomechanical indentation testing at the same anatomical locations. Seven bovine distal femoral condyles were prepared and a novel phantom filled with dilute gadolinium solution was rigidly attached to each specimen. High resolution MR images were acquired, and thickness indentation analysis of the cartilage was performed immediately after scanning. Segmentation of the MR data and cartilage thickness calculation was performed using semi-automated software. Registration of MR and indentation data was performed using the fluid filled phantom. The inter- and intra-examiner differences of the measurements were also determined. A total of 105 paired MRI-indentation thickness data points were analyzed, and a significant correlation between them was found (r=0.88, p<0.0001). The mean difference (±std. dev.) between measurement techniques was 0.00±0.23 mm, with Bland–Altman limits of agreement of 0.45 mm and −0.46 mm. The intra- and inter-examiner measurement differences were 0.03±0.22 mm and 0.05±0.24 mm, respectively. This study validated cartilage thickness measurements from MR images with thickness measurements from indentation by using a novel phantom to register the image-based and laboratory-based data sets. The accuracy of the measurements was comparable to previous cartilage thickness validation studies in literature. The results of this study will aid in validating a tool for clinical evaluation of in-vivo cartilage thickness.
publisherThe American Society of Mechanical Engineers (ASME)
titleValidation of Cartilage Thickness Calculations Using Indentation Analysis
typeJournal Paper
journal volume132
journal issue4
journal titleJournal of Biomechanical Engineering
identifier doi10.1115/1.4000989
journal fristpage41007
identifier eissn1528-8951
keywordsThickness
keywordsThickness measurement
keywordsCartilage
keywordsPhantoms
keywordsMeasurement AND Magnetic resonance imaging
treeJournal of Biomechanical Engineering:;2010:;volume( 132 ):;issue: 004
contenttypeFulltext


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