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contributor authorRonald P. Jean
contributor authorDarren S. Gray
contributor authorAlexander A. Spector
contributor authorChristopher S. Chen
date accessioned2017-05-09T00:12:16Z
date available2017-05-09T00:12:16Z
date copyrightOctober, 2004
date issued2004
identifier issn0148-0731
identifier otherJBENDY-26391#552_1.pdf
identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/129565
description abstractWe investigated the mechanotransduction pathway in endothelial cells between their nucleus and adhesions to the extracellular matrix. First, we measured nuclear deformations in response to alterations of cell shape as cells detach from a flat surface. We found that the nuclear deformation appeared to be in direct and immediate response to alterations of the cell adhesion area. The nucleus was then treated as a neo-Hookean compressible material, and we estimated the stress associated with the cytoskeleton and acting on the nucleus during cell rounding. With the obtained stress field, we estimated the magnitude of the forces deforming the nucleus. Considering the initial and final components of this adhesion-cytoskeleton-nucleus force transmission pathway, we found our estimate for the internal forces acting on the nucleus to be on the same order of magnitude as previously measured traction forces, suggesting a direct mechanical link between adhesions and the nucleus.
publisherThe American Society of Mechanical Engineers (ASME)
titleCharacterization of the Nuclear Deformation Caused by Changes in Endothelial Cell Shape
typeJournal Paper
journal volume126
journal issue5
journal titleJournal of Biomechanical Engineering
identifier doi10.1115/1.1800559
journal fristpage552
journal lastpage558
identifier eissn1528-8951
keywordsForce
keywordsDeformation
keywordsStress
keywordsShapes
keywordsEndothelial cells AND Traction
treeJournal of Biomechanical Engineering:;2004:;volume( 126 ):;issue: 005
contenttypeFulltext


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