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contributor authorJ. H. Omens
contributor authorS. M. Vaplon
contributor authorB. Fazeli
contributor authorA. D. McCulloch
date accessioned2017-05-08T23:55:49Z
date available2017-05-08T23:55:49Z
date copyrightDecember, 1998
date issued1998
identifier issn0148-0731
identifier otherJBENDY-26007#715_1.pdf
identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/120010
description abstractTheoretical considerations and observations of residual stress suggest that geometric remodeling in the heart may also alter residual stress and strain. We investigated whether changes in left ventricular geometry during physiologic growth were associated with corresponding changes in myocardial residual strain. In anesthetized rats from eight age groups ranging from 2–25+ weeks, the heart was arrested and isolated, and equatorial slices were obtained. The geometry of the intact, unloaded state was recorded, as well as the “opening angle” of the stress-free configuration after radial resection of the tissue slice. The tissue was fixed and embedded for histological examination of collagen area fraction. Heart weight increased 10-fold with age and unloaded internal radius increased almost 4-fold. However, wall thickness increased only 66 percent, so that the ratio of wall thickness to internal radius decreased significantly from 2.22 ± 0.29 (mean ± SD) at 2 weeks to 0.81 ± 0.47 at 25 weeks. Opening angle of the stress-free slice decreased significantly from 87 ± 16 deg at 2 weeks to 51 ± 16 deg, and correlated linearly with wall thickness/radius ratio. Collagen area fraction increased with age. Hence physiologic ventricular remodeling in rats decreases myocardial residual strain in proportion to the relative reduction in wall thickness–radius ratio.
publisherThe American Society of Mechanical Engineers (ASME)
titleLeft Ventricular Geometric Remodeling and Residual Stress in the Rat Heart
typeJournal Paper
journal volume120
journal issue6
journal titleJournal of Biomechanical Engineering
identifier doi10.1115/1.2834884
journal fristpage715
journal lastpage719
identifier eissn1528-8951
keywordsStress
keywordsWall thickness
keywordsPhysiology
keywordsBiological tissues
keywordsGeometry AND Weight (Mass)
treeJournal of Biomechanical Engineering:;1998:;volume( 120 ):;issue: 006
contenttypeFulltext


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