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contributor authorCheng Zhu
contributor authorGeert W. Schmid-Schönbein
contributor authorRichard Skalak
date accessioned2017-05-08T23:29:27Z
date available2017-05-08T23:29:27Z
date copyrightFebruary, 1989
date issued1989
identifier issn0148-0731
identifier otherJBENDY-25845#69_1.pdf
identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/105100
description abstractA one-dimensional steady state continuum mechanics model of retraction of pseudopod in leukocytes is developed. The retracting pseudopod is assumed to move bodily toward the main cell body, the bulk motion of which can be represented by cytoplasmic flow within a typical stream tube through the leukocyte. The stream tube is approximated by a frictionless tube with prescribed geometry. The passive rheological properties of cytoplasm in the main cell body and in the pseudopod are modeled, respectively, by Maxwell fluid and Hookean solid. The two regions are assumed to be separated by a sharp interface at which actin gel solates and thereby changes its rheological properties as it flows from the pseudopod to the main cell body. The driving mechanism responsible for the active retraction motion is hypothesized to be a spontaneous deformation of the actin gel, analogous but not necessarily equal to the well known actin-myosin interaction. This results in an active contractile stress being developed in the pseudopod as well as in the cell cortex. The transverse traction pulls against the inclined wall of the stream tube and is transduced into an axial stress gradient, which in turn drives the flow. The tension on the tube wall is picked up by the prestressed cortical shell. Governing equations and boundary conditions are derived. A solution is obtained. Sample data are computed. Comparison of the theory with experiments shows that the model is compatible to the observations.
publisherThe American Society of Mechanical Engineers (ASME)
titleOne-Dimensional Steady Continuum Model of Retraction of Pseudopod in Leukocytes
typeJournal Paper
journal volume111
journal issue1
journal titleJournal of Biomechanical Engineering
identifier doi10.1115/1.3168342
journal fristpage69
journal lastpage77
identifier eissn1528-8951
keywordsLeukocytes
keywordsFlow (Dynamics)
keywordsMotion
keywordsStress
keywordsContinuum mechanics
keywordsBoundary-value problems
keywordsEquations
keywordsGeometry
keywordsGradients
keywordsShells
keywordsSteady state
keywordsTension
keywordsTraction
keywordsDeformation
keywordsFluids AND Mechanisms
treeJournal of Biomechanical Engineering:;1989:;volume( 111 ):;issue: 001
contenttypeFulltext


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