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contributor authorCheng Dong
contributor authorKuo-Li Paul Sung
contributor authorG. W. Schmid-Schönbein
contributor authorShu Chien
contributor authorR. Skalak
date accessioned2017-05-08T23:26:47Z
date available2017-05-08T23:26:47Z
date copyrightFebruary, 1988
date issued1988
identifier issn0148-0731
identifier otherJBENDY-25833#27_1.pdf
identifier urihttp://yetl.yabesh.ir/yetl/handle/yetl/103682
description abstractThe following analysis presents an experimental and theoretical study of the passive viscoelastic behavior of human leukocytes. Individual neutrophils in EDTA were observed both during their partial aspiration into a small micropipette and after expulsion from a large micropipette where the cell had been totally aspirated and deformed into a sausage shape. To analyze the data, a passive model of leukocyte rheology has been developed consisting of a cortical shell containing a Maxwell fluid which describes the average properties of the cell cytoplasm. The cortical shell represents a crosslinked actin layer near the surface of the cell and is assumed to be under pre-stressed tension. This model can reproduce the results of experiments using micropipette for both short-time small deformation and slow recovery data after large deformation. In addition, a finite element scheme has been established for the same model which shows close agreement with the analytical solution.
publisherThe American Society of Mechanical Engineers (ASME)
titlePassive Deformation Analysis of Human Leukocytes
typeJournal Paper
journal volume110
journal issue1
journal titleJournal of Biomechanical Engineering
identifier doi10.1115/1.3108402
journal fristpage27
journal lastpage36
identifier eissn1528-8951
keywordsDeformation
keywordsLeukocytes
keywordsShells
keywordsTension
keywordsFluids
keywordsViscoelasticity
keywordsRheology
keywordsFinite element analysis AND Shapes
treeJournal of Biomechanical Engineering:;1988:;volume( 110 ):;issue: 001
contenttypeFulltext


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