contributor author | Cheng Dong | |
contributor author | Kuo-Li Paul Sung | |
contributor author | G. W. Schmid-Schönbein | |
contributor author | Shu Chien | |
contributor author | R. Skalak | |
date accessioned | 2017-05-08T23:26:47Z | |
date available | 2017-05-08T23:26:47Z | |
date copyright | February, 1988 | |
date issued | 1988 | |
identifier issn | 0148-0731 | |
identifier other | JBENDY-25833#27_1.pdf | |
identifier uri | http://yetl.yabesh.ir/yetl/handle/yetl/103682 | |
description abstract | The following analysis presents an experimental and theoretical study of the passive viscoelastic behavior of human leukocytes. Individual neutrophils in EDTA were observed both during their partial aspiration into a small micropipette and after expulsion from a large micropipette where the cell had been totally aspirated and deformed into a sausage shape. To analyze the data, a passive model of leukocyte rheology has been developed consisting of a cortical shell containing a Maxwell fluid which describes the average properties of the cell cytoplasm. The cortical shell represents a crosslinked actin layer near the surface of the cell and is assumed to be under pre-stressed tension. This model can reproduce the results of experiments using micropipette for both short-time small deformation and slow recovery data after large deformation. In addition, a finite element scheme has been established for the same model which shows close agreement with the analytical solution. | |
publisher | The American Society of Mechanical Engineers (ASME) | |
title | Passive Deformation Analysis of Human Leukocytes | |
type | Journal Paper | |
journal volume | 110 | |
journal issue | 1 | |
journal title | Journal of Biomechanical Engineering | |
identifier doi | 10.1115/1.3108402 | |
journal fristpage | 27 | |
journal lastpage | 36 | |
identifier eissn | 1528-8951 | |
keywords | Deformation | |
keywords | Leukocytes | |
keywords | Shells | |
keywords | Tension | |
keywords | Fluids | |
keywords | Viscoelasticity | |
keywords | Rheology | |
keywords | Finite element analysis AND Shapes | |
tree | Journal of Biomechanical Engineering:;1988:;volume( 110 ):;issue: 001 | |
contenttype | Fulltext | |