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RISA Mathematical Model for Postimplant Collagen Remodeling in an Autologous Engineered Pulmonary Arterial Conduit
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: This study was undertaken to develop a mathematical model of the long-term in vivo remodeling processes in postimplanted pulmonary artery (PA) conduits. Experimental results from two extant ovine in vivo studies, wherein ...
Simulation of Fatigue in Bioprosthetic Heart Valve Biomaterials1
Publisher: The American Society of Mechanical Engineers (ASME)
On the Three-Dimensional Correlation Between Myofibroblast Shape and Contraction
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Myofibroblasts are responsible for wound healing and tissue repair across all organ systems. In periods of growth and disease, myofibroblasts can undergo a phenotypic transition characterized by an increase in extracellular ...
Estimated in Vivo Postnatal Surface Growth Patterns of the Ovine Main Pulmonary Artery and Ascending Aorta
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Delineating the normal postnatal development of the pulmonary artery (PA) and ascending aorta (AA) can inform our understanding of congenital abnormalities, as well as pulmonary and systolic hypertension. We thus conducted ...
Insights Into Regional Adaptations in the Growing Pulmonary Artery Using a Meso Scale Structural Model: Effects of Ascending Aorta Impingement
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: As the next step in our investigations into the structural adaptations of the main pulmonary artery (PA) during postnatal growth, we utilized the extensive experimental measurements of the growing ovine PA from our previous ...
Neural Network Approaches for Soft Biological Tissue and Organ Simulations
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Given the functional complexities of soft tissues and organs, it is clear that computational simulations are critical in their understanding and for the rational basis for the development of therapies and replacements. A ...
The Accelerated Transcatheter Heart Valve Testing Environment: Loading, Motion, and Fluid Dynamics
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Transcatheter aortic valve replacements (TAVRs) are an increasingly common treatment for aortic valve disease due to their minimally invasive delivery. As TAVR designs require thinner leaflets to facilitate catheter-based ...
Simulated Effects of Acute Left Ventricular Myocardial Infarction on Mitral Regurgitation in an Ovine Model
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Ischemic mitral regurgitation (IMR) occurs from incomplete coaptation of the mitral valve (MV) after myocardial infarction (MI), typically worsened by continued remodeling of the left ventricular (LV). The importance of ...
A Generalized Method for the Analysis of Planar Biaxial Mechanical Data Using Tethered Testing Configurations
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: Simulation of the mechanical behavior of soft tissues is critical for many physiological and medical device applications. Accurate mechanical test data is crucial for both obtaining the form and robust parameter determination ...
A Novel Bioreactor for Mechanobiological Studies of Engineered Heart Valve Tissue Formation Under Pulmonary Arterial Physiological Flow Conditions
Publisher: The American Society of Mechanical Engineers (ASME)
Abstract: The ability to replicate physiological hemodynamic conditions during in vitro tissue development has been recognized as an important aspect in the development and in vitro assessment of engineered heart valve tissues. ...